What 'The Night Of' Gets So Right About Eczema

Eczema, a constellation of conditions that makes a person’s skin dry, itchy, red and scaly, affects an estimated 30 million Americans. It can shame and isolate people who have it.  And right now, the disease is having a moment in the sun thanks to its major role in HBO’s “The Night Of,” a crime drama mini-series that features a character who is heavily defined by having eczema. Played by John Turturro, lawyer John Stone is a disrespected “bottom feeder” attorney who usually hangs around NYPD precincts waiting for easy cases. He catches the trial of a lifetime when he wins the trust of Nasir Khan, a Pakistani-American college student accused of the grizzly rape and murder of a white woman from the Upper West Side. While Stone investigates, questions witnesses and visits Khan in prison, he’s also constantly having to soothe his inflamed skin. It’s mostly on his feet, but it’s creeping up his legs and has spread to his neck and back. Peter Moffat, the writer who created the U.K. series on which “The Night Of” is based, has eczema himself and wrote it into the original show, but U.S. writers Richard Price and Steven Zaillian said they expanded eczema’s role in their version after doing more research on it. In a panel, Price called the disease a “metaphor for the frustrations of finding a solution and the entire judicial system.” Experts aren’t sure what causes eczema, but they think it&...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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ConclusionsPillar suture combined with tonsillectomy may reduce postoperative bleeding incidence despite increasing pillar edema in pediatric tonsillectomy. Postoperative pain-relief, palatal hematoma, palatal discomfort sensation, site infection, and velopharyngeal insufficiency were not significantly altered compared to tonsillectomy alone. However, further studies are needed to corroborate the results of this study.ResumoIntroduçãoDiversas técnicas cirúrgicas têm sido utilizadas na tonsilectomia no intuito de reduzir complicações.ObjetivosAvaliar os efeitos da sutura dos p...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Publication date: Available online 25 January 2020Source: International Journal of PharmaceuticsAuthor(s): Xue Zheng, Chao Sun, Rilei Yu, Xin Chu, Jiahao Xu, Chengcheng Liu, Miaoqing Zhao, Xuelian Xu, Ming Xia, Cheng WangAbstractRelapse in Allergic Rhinitis (AR) is triggered by various unclear mechanisms. Xanthium strumarium L. as a traditional folk medicine can inhibit inflammatory responses through multiple mechanisms. Xanthatin (XT) is a bioactive compound derived from Xanthium strumarium L, and we developed a polymeric micelle (PM) that is dendritic cells (DCs)-specific targeting delivery system loading XT (NGR-XT-PM) ...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
ConclusionsCMR is a key tool for diagnosing LDAC. Characteristic findings are subepicardial fatty infiltration and midwall-subepicardial late gadolinium enhancement. The prognosis of this population is poor with a high incidence of sudden cardiac death and ventricular arrhythmias.ResumenIntroducción y objetivosRecientemente, la miocardiopatía arritmogénica del ventrículo izquierdo (MCAVI) ha sido reconocida como parte del espectro de la miocardiopatía arritmogénica. Se caracteriza por el reemplazo fibroadiposo de la pared de dicho ventrículo. Se describen las formas de prese...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 25 January 2020Source: Anaesthesia &Intensive Care MedicineAuthor(s): Peter Carachi, Glyn WilliamsAbstractAcute pain management in the neonatal period remains a challenge for the clinician. Responses to pain and analgesic intervention are developmentally influenced and cannot be directly extrapolated from the older child. Successful and safe intervention will minimize acute physiological and behavioural distress, reduce pain scores and potentially improve short- and long-term outcomes. This requires an understanding of the physiology and pharmacology in this age group alongside a mult...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Conclusion: It may be employed either alone or in combination with cryotherapy, existing chemotherapy, bypass surgery or radiations to achieve the optimal results in these patients. Nevertheless, there is a need to formulate a uniform dose and procedure to achieve homogeneity and develop references for clinical practices. PMID: 31977258 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Conclusions: Antioxidants that are not specifically targeted to mitochondria fail to accumulate in significant amounts in critical sites of mitochondrial ROS production and may eventually interfere with the ensuing physiological signaling. Mitochondria-targeted antioxidants are more effective, but are expected to interfere with the mitochondrial ROS-dependent physiologic signaling. AA promotes multiple beneficial effects in mitochondria. The complex regulation of vitamin C uptake in these organelles likely contributes to its versatile antioxidant response, thereby providing a central role to the vitamin for adequate contro...
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Publication date: Available online 9 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Federico Lavorini, Celeste Barreto, Job F.M. van Boven, Will Carroll, Joy Conway, Richard W. Costello, Birthe Hellqvist Dahl, Richard P.N. Dekhuijzen, Stephen Holmes, Mark Levy, Mathieu Molimard, Nicholas Roche, Miguel Román-Rodriguez, Nicola Scichilone, Jane Scullion, Omar S. UsmaniSpacers are pressurized metered-dose inhaler (pMDI) accessory devices developed to reduce problems of poor inhaler technique with pMDIs. Spacers that feature a 1-way inspiratory valve are termed valved holding ch...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
CONCLUSION: Conventional exercises together with diaphragm training result in a greater improvement than conventional exercises alone. PMID: 31974590 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
Affinity improvement of the fully human anti‑TSLP recombinant antibody. Mol Med Rep. 2020 Feb;21(2):759-767 Authors: Chen Q, Xian D, Xu W, Nian S, Yu H, Wu Y, Yuan Q Abstract Thymic stromal lymphopoietin (TSLP) is a potentially important target for the treatment of asthma and malignancies. However, a fully human antibody reactive with TSLP is currently unavailable for clinical use. In a previous study, a human anti‑TSLP‑single‑chain antibody variable fragment (anti‑TSLP‑scFv) 84 was selected by phage display from a constructed human scFv library. In the present study, a computer simulation ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Authors: Haese N, Powers J, Streblow DN Abstract Chikungunya virus (CHIKV) infection in humans is rarely fatal but is often associated with chronic joint and muscle pain. Chronic CHIKV disease is highly debilitating and is associated with viral persistence. To date, there are no approved vaccines or therapeutics to prevent or treat CHIKV infections once they are established. Current palliative treatments aim to reduce joint inflammation and pain associated with acute and chronic CHIKV disease. Development of novel therapeutics that reduces viral loads should positively impact virus inflammatory disease and improve ...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
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