Structural analysis of point mutations at the Vaccinia virus A20/D4 interface

This study confirms previous biochemical data and also points out the importance for stability of the restrained conformational space of Pro173. Moreover, these new structures will be useful for the design and rational improvement of known molecules targeting the D4/A20 interface.

Source: Acta Crystallographica Section F - August 8, 2016 Category: Biochemistry Authors: Contesto-Richefeu, C. Tarbouriech, N. Brazzolotto, X. Burmeister, W.P. Peyrefitte, C.N. Iseni, F. Tags: Vaccinia virus DNA replication X-ray structure – π interaction protein protein interface research communications Source Type: research