Circulating levels of soluble low-density lipoprotein receptor-related protein 1 (sLRP1) as novel biomarker of epicardial adipose tissue

Epicardial adipose tissue (EAT) is not only a lipid storage organ but also a metabolic active and endocrine organ that secrete a number of inflammatory and endocrine mediators [1]. Under normal physiological conditions, EAT exerts cardioprotective actions [2], but under pathophysiological circumstances, such as metabolic syndrome or obesity, EAT has been associated with cardiometabolic disease [3]. Indeed, EAT thickness and/or volume has been directly associated with diabetes, hypertension, atrial fibrillation, heart failure and coronary artery disease [3,4].
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research