Large New Study Shows No Link Between IVF And Breast Cancer

There's good news for the many women who have asked their fertility specialist over the years whether there's a link between in vitro fertilization (IVF) and an increased risk of breast cancer. Since IVF involves a temporary increase in hormones - five to ten times higher than normal including hormones that can impact the growth of specific types of breast cancer - it's a fair question. Now, results from the largest, most comprehensive study to date just published in JAMA show no population-wide link. This confirms research of the past few years and counters a few small, earlier studies that concluded otherwise. It is confusing. Various studies over the past ten years have also shown no link between breast cancer and IVF but experts remained cautious as women participating in the research who had IVF treatment during the 1980s had not yet reached menopause. For the latest research "The main takeaway is there's no evidence of an increased subsequent risk of breast cancer, at least in the first couple decades," said Dr. Saundra S. Buys, an oncologist at the Huntsman Cancer Institute at the University of Utah, who was not involved in the new study. The issue has been around for a while fueled by earlier studies with differing results. An analysis in 2013 of eight studies concluded tentatively that IVF did "not raise the risk of breast cancer over all." Still, experts worried that looking at larger numbers of women over a much longer period of time could ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Authors: Karczewski J, Śledzińska E, Baturo A, Jończyk I, Maleszko A, Maleszko A, Samborski P, Begier-Krasińska B, Dobrowolska A Abstract The prevalence of obesity has recently increased dramatically and has contributed to the increasing prevalence of various pathological conditions, including type 2 diabetes mellitus, nonalcoholic fatty liver disease, asthma, various types of cancer, cardiovascular and neurodegenerative diseases, and others. Accumulating evidence points to localized inflammation in adipose tissue, which, in turn, promotes systemic low-grade inflammation as a primary force contributing to the d...
Source: European Cytokine Network - Category: Molecular Biology Tags: Eur Cytokine Netw Source Type: research
In conclusion, inflammatory cytokines and adipokines seem to have a pivotal role in the regulation of spermatogenesis; any imbalance in this stable environment may lead to infertility. Nevertheless, further studies are needed to clarify their exact role. PMID: 30547889 [PubMed - in process]
Source: European Cytokine Network - Category: Molecular Biology Tags: Eur Cytokine Netw Source Type: research
CONCLUSION: Bone pain is a common and sometimes severe symptom of bone metastases in advanced breast cancer and a common reason for initiating BTA treatment. Safety and efficacy were the main factors considered by physicians when selecting BTAs. Past Presentations: Data previously presented at the ISPOR 18th Annual European Congress, Milan, Italy; November 7-11, 2015 and at the Breast Cancer Symposium, San Francisco, CA, USA; September 25-27, 2015. PMID: 30550358 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
CONCLUSIONS: Although the use of PP-CSF is commonplace in current US clinical practice, underutilization in cancer patients receiving chemotherapy regimens with an intermediate/high-risk for FN may still be an issue. Use of same-day PP-CSF increased markedly from the end of 2015, although this finding reflects (at least in part) increased uptake of pegfilgrastim delivered via an on-body injector as well as the recent change in clinical practice guidelines. Overall, patients receiving PP-CSF appear to have a lower risk of FN during the first cycle of chemotherapy. PMID: 30550346 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Publication date: Available online 16 December 2018Source: European UrologyAuthor(s): Anwar R. Padhani, Masoom A. Haider, Arnauld Villers, Jelle O. Barentsz
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 15 December 2018Source: European UrologyAuthor(s): Yongbao Wei, Tao Li, Longfei Liu
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 16 December 2018Source: Journal of Minimally Invasive GynecologyAuthor(s): Yoichi Aoki, Hiroyuki Kanao, Iwaho Kikuchi, Hidetaka Nomura, Syuhei Okamoto, Tsuyoshi Hisa, Takeru Sugihara, Rie Kitano, Kohei Omatsu, Terumi Tanigawa, Nobuhiro TakeshimaAbstractStudy ObjectiveTo compare 3 laparoscopic contained morcellation techniques in terms of feasibility and safety.DesignPilot study in an animal model (Canadian Task Force classification II-1).SettingGynecologic oncology department at a cancer institute in Japan.PatientsPorcine Model.InterventionsThree contained morcellation techniques were tes...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Daniela Guardado-Félix, Marilena Antunes-Ricardo, María R. Rocha-Pizaña, Ana-Carolina Martínez-Torres, Janet A. Gutiérrez-Uribe, Sergio O. Serna SaldivarAbstractThe effect of selenium enriched chickpea sprouts with and without isoflavonoids (IS) on colorectal cancer (CRC) tumor growth was evaluated in immune-suppressed mice xenografted. Two levels of selenium (0.17 and 2.29 µg/g) and isoflavonoids (0 and 2.34 mg/g) were evaluated in the diets. High intake of Se (2.29 µg/g) with and wi...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Authors: Agrawal P, Heimbruch KE, Rao S Abstract Gene expression is regulated by numerous elements including enhancers, insulators, transcription factors, and architectural proteins. Regions of DNA distal to the transcriptional start site, called enhancers, play a central role in the temporal and tissue-specific regulation of gene expression through RNA polymerase II. The identification of enhancers and other cis regulatory elements has largely been possible due to advances in next generation sequencing technologies. Enhancers regulate gene expression through chromatin loops mediated by architectural proteins such ...
Source: Comprehensive Physiology - Category: Physiology Tags: Compr Physiol Source Type: research
Women who smoke and those who have been exposed to second hand smoke have more problems getting pregnant and are more likely to reachmenopause at an earlier age than women who never smoked or those who were exposed to the least amount of second hand smoke. A new investigation from Roswell Park Cancer Institute reached these conclusions after researchers analyzed data on nearly 89,000 women in the U.S. Women who reported smoking were 14 percent more likely to have infertility (meaning that they were unable to get pregnant for a year) and 26 percent more likely to reach menopause earlier than women who didn’t smoke. Th...
Source: Dr. Weil's Daily Health Tips - Category: Consumer Health News Authors: Tags: Science and Supplement News fertility menopause women's health Source Type: blogs
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