Large New Study Shows No Link Between IVF And Breast Cancer

There's good news for the many women who have asked their fertility specialist over the years whether there's a link between in vitro fertilization (IVF) and an increased risk of breast cancer. Since IVF involves a temporary increase in hormones - five to ten times higher than normal including hormones that can impact the growth of specific types of breast cancer - it's a fair question. Now, results from the largest, most comprehensive study to date just published in JAMA show no population-wide link. This confirms research of the past few years and counters a few small, earlier studies that concluded otherwise. It is confusing. Various studies over the past ten years have also shown no link between breast cancer and IVF but experts remained cautious as women participating in the research who had IVF treatment during the 1980s had not yet reached menopause. For the latest research "The main takeaway is there's no evidence of an increased subsequent risk of breast cancer, at least in the first couple decades," said Dr. Saundra S. Buys, an oncologist at the Huntsman Cancer Institute at the University of Utah, who was not involved in the new study. The issue has been around for a while fueled by earlier studies with differing results. An analysis in 2013 of eight studies concluded tentatively that IVF did "not raise the risk of breast cancer over all." Still, experts worried that looking at larger numbers of women over a much longer period of time could ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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(American Association for Cancer Research) A deep-learning model developed using serial image scans of tumors from patients with non-small cell lung cancer (NSCLC) predicted treatment response and survival outcomes better than standard clinical parameters.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(Wiley) A new study reveals that many people with cancer use marijuana, and rates of use in the US have increased over time. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study also found that patients with cancer are more likely to use prescription opioids than adults without cancer.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Contributors : Yu-Chan Chang ; Michael HsiaoSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe demonstrate that RAB3C up-regulation significantly promoted cell migration and invasion in lower invasive colon cancer cell lines in vitro, as well as in distal metastases in vivoWe used microarrays to analyze the RAB3C regulated gene expression underlying invasion-metastasis cascade.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Publication date: Available online 21 April 2019Source: Journal of Molecular StructureAuthor(s): Rafael G. Silveira, Beatriz N. Cunha, Juan C. Tenório, Deborah Victória Alves de Aguiar, Patricia da Cruz Souza, Boniek Gontijo Vaz, Javier Ellena, Alzir A. Batista, Felipe Terra MartinsAbstractAbiraterone acetate is a first choice prodrug to treat prostate cancer. New higher-solubility multicomponent crystal forms of the active compound abiraterone could substitute for the commonly used acetate prodrug. Here we prepare abiraterone hydrochloride monohydrate, which is the first multicomponent crystal form of this s...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study, we screened a siRNA library targeting 6024 human genes and identified Ku80 as a potential therapeutic target in melanoma cells. Knockdown of Ku80 significantly suppressed melanoma cell proliferation and induced apoptosis, as well as enhanced the antitumor effect of melatonin in melanoma in vitro and in vivo. Overexpression of Ku80, however, promoted melanoma growth and increased the insensitivity of melanoma cells to melatonin. Mechanistically, we found that Ku80 bound to the PDK1 promoter and activated the transcription of PDK1. Moreover, we showed that the binding of Ku80 at the PDK-1 promoter was HIF1-&al...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: 1 August 2019Source: Carbohydrate Polymers, Volume 217Author(s): Yalda Rahbar Saadat, Ahmad Yari Khosroushahi, Bahram Pourghassem GargariAbstractSeveral scientific evidences have revealed probiotics implications on human health. A wide range of lactic acid bacteria (LAB) have been extensively studied for their ability to produce extracellular polysaccharides (EPSs), which are repeating units of mono/oligosaccharides with various chemical compositions and properties. Despite the conventional belief regarding probiotics that states bacteria must be alive to exert their beneficial effects, mounting evidence ...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 20 April 2019Source: Inorganica Chimica ActaAuthor(s): Dhrubajyoti Majumdar, Sourav Das, Renjith Thomas, Zakir Ullah, S.S. Sreejith, Dhiraj Das, Pooja Shukla, Kalipada Bankura, Dipankar MishraAbstractTwo new dicyanamide modulated zinc metal complexes [Zn4(LOMe)2(µ1-dca)2(µ1,5-dca)2] (1) and [Zn3(LOEt)2(H2O)(µ1-dca)(µ1,5-dca)](2) have been synthesized using H2vanen-type compartmental ligands. Schiff base ligands and the complexes were characterized by means of elemental analyses, FT-IR, FT-Raman, UV-Visible, powder X-ray diffraction, TGA and fluorescence spectroscop...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 20 April 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): B.E. Amantea, R.D. Piazza, J.R.V Chacon, C.C. Santos, T.P. Costa, C.O. Rocha, J.V. Brandt, D.R.M. Godoi, M. Jafelicci, R.F.C. MarquesAbstractThe ability to generate heat from magnetic nanoparticle and the response of thermosensitive polymers poly(n-isopropylacrylamide) (PNIPAm) and poly(n-vinyl caprolactam) (PNVCL) are properties that have promoted several studies in controlled drug release systems. As the lower critical solution temperatures (LCST) of PNIPAm and PNVCL are between 32-35 ...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
AbstractIntroductionBased on the observation of beneficial effects on cancer metabolism, microenvironment, or VEGF-signaling, several non-anticancer drugs have been discussed as useful in renal cell carcinoma (RCC). In the present study, we investigated the prognostic impact of concomitant medication in RCC and correlated comedication with cell-cycle and proliferation activity in corresponding surgical specimen.MethodsA total of 388 patients who underwent surgery for localized RCC were included. The individual medication was evaluated according to substance classes. Tissue microarrays from corresponding tumor specimen were...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Women who smoke and those who have been exposed to second hand smoke have more problems getting pregnant and are more likely to reachmenopause at an earlier age than women who never smoked or those who were exposed to the least amount of second hand smoke. A new investigation from Roswell Park Cancer Institute reached these conclusions after researchers analyzed data on nearly 89,000 women in the U.S. Women who reported smoking were 14 percent more likely to have infertility (meaning that they were unable to get pregnant for a year) and 26 percent more likely to reach menopause earlier than women who didn’t smoke. Th...
Source: Dr. Weil's Daily Health Tips - Category: Consumer Health News Authors: Tags: Science and Supplement News fertility menopause women's health Source Type: blogs
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