Notolutesin K −P, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus collenchymatosus

Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Jing-Yi Wu, Xiao Wang, Jiao-Zhen Zhang, Jin-Chuan Zhou, Lin Li, Hong-Xiang Lou Six new dolabrane-type diterpenoids, notolutesin K–P (1–6), were isolated from the Chinese liverwort Notoscyphus collenchymatosus, along with five known dolabrane derivatives and a known pimarane derivative. Their structures were elucidated on the basis of extensive analysis of spectroscopic data. Cytotoxicity test against a panel of human cancer cell lines demonstrated that compound 6 showed cytotoxic activity with IC50 values range from 3.50 to 5.20μM. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research