Compound Shows Promise as Next-Generation Prostate Cancer Therapy

Contact: Sarah Avery Phone: 919-660-1306 Email:sarah.avery@duke.eduhttps://www.dukehealth.orgEMBARGOED FOR RELEASE until 11 a.m. (ET) Monday, Aug. 8, 2016DURHAM, N.C. -- In the search for new ways to attack recurrent prostate cancer, researchers at Duke Health report that a novel compound appears to have a unique way of blocking testosterone from fueling the tumors in mice.The potential foundation for a next-generation therapy, called tetraaryl cyclobutane, or CB, is being studied as an option for prostate tumors that have grown resistant to current anti-androgen drugs, notably enzalutamide.“Prostate cancer is the most prevalent form of cancer in men, and the principal driver of tumor growth is the androgen receptor,” saidJohn D. Norris, Ph.D., associate research professor in theDepartment of Pharmacology&Cancer Biology at Duke and senior author of a study published online Aug. 8 in the journal Nature Chemical Biology.“Suppression of androgen receptor function by anti-endocrine therapies is initially effective, but most tumors develop resistance, resulting in a more aggressive cancer,” Norris said. “Our research has been focused on finding a new approach to suppressing androgen receptor activity, because ev en in situations where tumors are resistant to current therapies, the androgen receptor remains a viable target.”Norris and colleagues focused on a group of CB compounds developed in collaboration with scientists at the Universi...
Source: DukeHealth.org: Duke Health Features - Category: Pediatrics Tags: Duke Medicine Source Type: news

Related Links:

ConclusionBased on these criteria, the scientific impact of large phase III cancer chemoprevention trials was very high in absolute terms, and as good as or better than that of treatment trials after accounting for expenditure. For appropriate scientific questions, large chemoprevention trials provide a good scientific return on investment for federal funding agencies.Graphical abstract
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
ConclusionPatients with cancer begin to increase their consultation frequency in general practice before a cancer diagnosis independently of their usual consultation frequency.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
(CNN) — People who eat dinner before 9 p.m. — or at least two hours before going to sleep — have a 20% lower risk of breast and prostate cancer than those who eat after 10 p.m. or go to bed shortly after supper, researchers found. “The mechanisms are not clear,” said Dr. Manolis Kogevinas, a research professor at the Barcelona Institute for Global Health in Spain and lead author of a new study on the topic. “What we know from experimental studies is that we are conditioned to function in different parts of the day. We — not only humans but all living organisms — have develope...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Cancer Local TV Source Type: news
WEDNESDAY, July 18, 2018 -- Having a late dinner and heading straight to bed may boost your risk of breast or prostate cancer, a new study suggests. Spanish researchers analyzed data from 621 prostate cancer patients and 1,205 breast cancer...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
The NCI Laboratory of Cancer Biology and Genetics seeks parties interested in collaborative research to further develop this mouse model of triple-negative breast cancer (TNBC) to study cancer biology and for preclinical testing.   As a Research Tool, patent protection is not being pursued for this technology. Basal triple-negative breast cancer (TNBC) is a common form of human breast cancer for which there are no specific, targeted therapies, unlike hormone-responsive or Her2+ breast cancers. TNBC has a much worse prognosis than hormone receptor + cancer and is disproportionately high in the African-American populati...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
In this study, for the very first time waterborne TESP was performed in the presence of MNPs. Neat MNPs were coated and in situ functionalized with amine groups by using thiol-ene chemistry. Engrailed-2 (EN2) protein, a potential biomarker for various cancers such as prostate cancer, bladder cancer, breast cancer and ovarian cancer, is known to be a strong binder to a specific DNA sequence (50-TAATTA-30) to regulate transcription. Anti-EN2 antibodies were immobilized onto these MNPs by physical adsorption and covalent bonding methods, respectively. The amount of the physically immobilized antibodies (0.54 mg/g) were foun...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 20 March 2018Source: The Lancet Diabetes &EndocrinologyAuthor(s): Tilman D Rachner, Robert Coleman, Peyman Hadji, Lorenz C HofbauerSummaryPreservation of bone health remains a long-term clinical challenge in patients with breast and prostate cancer. Osteoporosis, defined by a loss of bone mass and microarchitecture, often results in fragility fractures that are typically associated with a high socioeconomic burden. Endocrine therapy, a mainstay treatment in the management of patients with hormone-sensitive breast and prostate cancer in the adjuvant setting, commonly exerts adverse eff...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 18 June 2018Source: Molecular and Cellular EndocrinologyAuthor(s): Todd K. Parsons, Rachel N. Pratt, Li Tang, Yue WuAbstractSteroid hormones play important roles in normal physiological functions and diseases. Sex steroids hormones are important in the biology and treatment of sex hormone-related cancer such as prostate cancer and breast cancer. Cells may take up steroids using multiple mechanisms. The conventionally accepted hypothesis that steroids cross cell membrane through passive diffusion has not been tested rigorously. Experimental data suggested that cells may take up sex steroid...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 7 July 2018Source: SteroidsAuthor(s): Nguyen Hoai Nam, Ninh Thi Ngoc, Tran Thi Hong Hanh, Nguyen Xuan Cuong, Nguyen Van Thanh, Do Thi Thao, Do Cong Thung, Phan Van Kiem, Chau Van MinhAbstractUsing various chromatographic separations, seventeen steroids including seven new compounds, verrucorosteroids A−F (1−6) and verrucorosterone (7), were isolated from the Vietnamese gorgonian Verrucella corona. Their structures were elucidated by spectroscopic analysis, including HR QTOF MS, 1D and 2D NMR. Among isolates, verrucorosterone (7), 5,6α-epoxy-3β-hydroxy-(22E)-ergosta-...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
ConclusionsIndependent trials indicate that the PMR–GI combination is an effective way to tackle the impact of nausea and vomiting and to improve patients’ mental state. However, studies involving other types of primary tumors would be useful because seven of the eight clinical trials only included breast cancer patients. Future research on the identification of potential effects on disease-related parameters (e.g., cytokines and disease-recurrence) and on patient survival is highly needed.
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
More News: Biology | Breast Cancer | Cancer | Cancer & Oncology | Cancer Therapy | Chemistry | Drugs & Pharmacology | Endocrine Therapy | Health | Legislation | National Institutes of Health (NIH) | Pediatrics | Politics | Prostate Cancer | Research | Study