R ‐ and S‐citalopram concentrations have differential effects on neuropsychiatric scores in elders with dementia and agitation
ConclusionsOur results suggest that citalopram enantiomers contributed differentially to treatment outcomes. (R)‐citalopram accounted for a greater proportion of the adverse consequences associated with racemic citalopram treatment in patients with AD including a decreased probability of treatment response as measured by the CGIC and a reduction in MMSE scores. The S‐enantiomer was associated with increased probability of response based on the CGIC.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Thang Ho, Bruce G. Pollock, Benoit H. Mulsant, Oliver Schantz, Devangere P. Devanand, Jacobo E. Mintzer, Anton P. Porsteinsson, Lon S. Schneider, Daniel Weintraub, Jerome Yesavage, Lea T. Drye, Cynthia A. Munro, David M. Shade, Constantine Lyketsos, Rober Tags: PHARMACOKINETIC DYNAMIC RELATIONSHIPS Source Type: research