Case from yesterday

Hey all, had a case yesterday that I want to hear from you all about. 75 year old male marine Vet, h/o severe COPD on home oxygen and several meds (albuterol neb 4x/day, symbicort, spiriva, daliresp, a few weeks ago started on prednisone taper down to 5 mg/day), h/o MI and severe PVD, h/o PE on Xarelto (last taken a little less than 2.5 days prior), IDDM, a hint of dementia and anxiety, comes in for a hip fracture after falling. You see him on oxygen, sitting in bed, speaking in somewhat... Case from yesterday
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums

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Abstract Adenosine is a purine nucleoside, responsible for the regulation of a wide range of physiological and pathophysiological conditions by binding with four G-protein-coupled receptors (GPCRs), namely A1, A2A, A2B and A3 adenosine receptors (ARs). In particular, A1 AR is ubiquitously present, mediating a variety of physiological processes throughout the body, thus represents a promising drug target for the management of various pathological conditions. Agonists of A1 AR are found to be useful for the treatment of atrial arrhythmia, angina, type-2 diabetes, glaucoma, neuropathic pain, epilepsy, depression and ...
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Pharm Des Source Type: research
CONCLUSION: We found no significant association of levothyroxine treatment and incident dementia among patients with AF, which contrasts some earlier findings. PMID: 31119696 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - Category: Geriatrics Authors: Tags: Aging Clin Exp Res Source Type: research
This study suggests that advantages and disadvantages vary by environment and diet, however, which might explain why evolution has selected for multiple haplogroups rather than one dominant haplogroup. This is all interesting, but none of it stops the research community from engineering a globally better-than-natural human mitochondrial genome, and then copying it into the cell nucleus as a backup to prevent the well-known contribution of mitochondrial DNA damage to aging. Further, nothing stops us from keeping the haplogroups we have and rendering the effects of variants small and irrelevant through the development...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: This study emphasizes the impact of comorbidities and its real burden in COPD. For better outcomes and quality of life each comorbidity should be individually assessed and treated
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
CONCLUSION: The study emphasizes the identification of factors associated with the prescription of PIMs during the first completed comprehensive geriatric assessment. Targeted strategies to reduce modifiable factors associated with the prescription of PIMs in subsequent assessments has the potential to improve medication management in older adults. PMID: 30380343 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
DiscussionCOPD is known to be associated with the development of cognitive deficits, in particular, regarding for executive functions and attention, memory and logical reasoning. In this context, MMSE has a low diagnostic accuracy to underline effective cognitive impairment in AD-COPD. Our study shows a higher frequency of frontal deficits and behavioral disturbances in patients with AD and COPD than patients with AD-only. COPD could complicate the management of AD patients, thus necessitating a closer and multidisciplinary monitoring.
Source: Neurological Sciences - Category: Neurology Source Type: research
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-ea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions:IR may confer risk of developing LOHD. Contributing factors may include comorbid neurodegenerative pathologies given advanced age or presence of other disease-modifying genes. Future longitudinal cohorts studying incidence of symptoms will be essential for understanding the spectrum of genetic susceptibility.Disclosure: Dr. McDermott has nothing to disclose. Dr. Bang has nothing to disclose. Dr. Liptak has nothing to disclose. Dr. Krishnakumar has nothing to disclose. Dr. Nelson has nothing to disclose. Dr. Geschwind has received personal compensation for activities with Best Doctors, Advanced Medical, Guidepoi...
Source: Neurology - Category: Neurology Authors: Tags: Movement Disorders: Huntington ' s Disease, Chorea & amp;amp; Tardive Dyskinesia Source Type: research
Conclusion: These results support the validity and reliability of the new tablet-based electronic Columbia-Suicide Severity Rating Scale. This will allow the inclusion of the electronic Columbia-Suicide Severity Rating Scale in a wider range of clinical studies, particularly where a tablet is also being used to collect other study data. Introduction Prospective assessment of suicidal ideation and behavior (SIB) is a critical step in many clinical trials. The United States Food and Drug Administration (FDA) mandates prospective SIB in “all clinical trials involving any drug being developed for any psychiatric indicati...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools Current Issue Depression Devices Drug Development Evaluations Original Research Patient Assessment Psychiatry Scales Suicidality Technology Trial Methodology C-SSR Columbia-Suicide Severity Rating Scale elect Source Type: research
Conditions:   Hypertension;   Depression;   Anxiety;   Musculoskeletal Pain;   Arthritis;   Rheumatoid Arthritis;   Osteoporosis;   Chronic Obstructive Pulmonary Disease (COPD);   Asthma;   Chronic Bronchitis;   Cardiovascular Disease;   Heart Failure;   Stroke;   Transient Ischemic Attacks;   Ulcer;   Gastroesophageal Reflux;   Irritable Bowel;   Crohn's Disease;   Ulcerative Colitis;   Diverticulosis;   Chronic Hepatitis;   Diabetes; ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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