What is the Intraarticular Concentration of Tobramycin Using Low-dose Tobramycin Bone Cement in TKA: An In Vivo Analysis?

CONCLUSIONS: Tobramycin-impregnated bone cement provides a way to deliver antibiotics in patients undergoing TKA. This supratherapeutic short-term prophylactic perioperative antibiotic local delivery can be achieved with limited systemic absorption, whereas joint tobramycin levels were less than therapeutic levels when given intravenously alone. In the control group, with only intravenous tobramycin, a subtherapeutic (< 2.0 μg/mL) level of tobramycin was found in all the intraarticular samples at 6, 24, and 48 hours. Based on the evidence obtained in this study, commercially prepared low-dose tobramycin bone cement can be used to obtain short-term supratherapeutic local concentrations in the knee while maintaining serum tobramycin levels at a minimum.
LEVEL OF EVIDENCE: Level II, therapeutic study.
PMID: 27488378 [PubMed - as supplied by publisher]

Source: Clinical Orthopaedics and Related Research - August 2, 2016 Category: Orthopaedics Authors: Vrabec G, Stevenson W, Elguizaoui S, Kirsch M, Pinkowski J Tags: Clin Orthop Relat Res Source Type: research