Detection of Colorectal Cancer Using a Simplified SEPT9 Gene Methylation Assay Is a Reliable Method for Opportunistic Screening
SEPT9 gene methylation was validated as a biomarker for colorectal cancer (CRC) for>10 years and available as the Epi proColon test as an aid in CRC detection for>6 years. It was proven to be an accurate, reliable, fast, and convenient molecular test. In this opportunistic screening study, we validated a further simplified SEPT9 gene methylation assay in 1031 subjects in Chinese hospitals. The sensitivity for CRC detection was 76.6% at a specificity of 95.9%, and the results showed a satisfactory detection rate for each CRC stage, including early stages.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Dong Wu, Guangpeng Zhou, Peng Jin, Jiqing Zhu, Shijie Li, Qi Wu, Guiqi Wang, Jianqiu Sheng, Jianming Wang, Lele Song, Xiaoliang Han, Jiaming Qian Tags: Regular article Source Type: research
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