Rapid Molecular Profiling of Myeloproliferative Neoplasms Using Targeted Exon Resequencing of 86 Genes Involved in JAK-STAT Signaling and Epigenetic Regulation

Myeloproliferative neoplasms (MPNs) are a heterogeneous group of blood disorders characterized by excess production of mature blood cells and an increased risk of late transformation to acute myeloid leukemia or primary myelofibrosis. Approximately 15% of MPN cases do not carry mutations in JAK2, CALR, or MPL and are thus often referred to as triple-negative cases. These are caused by a diverse set of rare mutations in cytokine receptors, Janus kinase-STAT signaling pathway components, or epigenetic modifiers.

Source: Journal of Molecular Diagnostics - July 18, 2016 Category: Pathology Authors: Graham W. Magor, Michael R. Tallack, Nathan M. Klose, Debra Taylor, Darren Korbie, Peter Mollee, Matt Trau, Andrew C. Perkins Tags: Regular Article Source Type: research