Transient decrease of hepatic NAD + and amino acid alterations during treatment with  valproate: new insights on drug-induced effects in vivo using targeted MS-based metabolomics

ConclusionThe observed accumulation of kynurenine intermediates in rat liver tissue suggests a drug-induced interference with the de novo pathway of NAD+ biosynthesis. These findings provide novel insights into the mechanisms of VPA associated hepatocellular dysfunction and/or toxicity, but with possible major relevance to the anticancer effects of the drug.
Source: Metabolomics - Category: Biology Source Type: research