Pattern and outcome of tetanus in a tertiary health facility in north west nigeria.

PATTERN AND OUTCOME OF TETANUS IN A TERTIARY HEALTH FACILITY IN NORTH WEST NIGERIA. Ethiop Med J. 2016 Apr;54(2):69-75 Authors: Aliyu A, Dahiru T, Obiako RO, Amadu L, Biliaminu LB, Akase EI Abstract BACKGROUND: Tetanus, a disease that is largely preventable, is still a major public health problem in the developing world and is associated with high morbidity and mortality. There is a paucity of published literature on adult (non-neonatal) tetanus in this study area in Nigeria. METHODS: This was a study describing the clinical characteristics of patients who were clinically diagnosed with tetanus in Ahmadu Bello University Teaching Hospital (ABUTH) Zaria, northwest of Nigeria between January 2001 and December 2014. RESULTS: A total of 91 cases were reviewed. The mean patient age was 20 years, and male to female ratio 2.9:1. The majority (88%) of patients were
Source: Ethiopian Medical Journal - Category: African Health Tags: Ethiop Med J Source Type: research

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Contributor : Jeroen PenningsSeries Type : OtherOrganism : Clostridium tetaniTo develop a method for improved assessment of the genetic stability of bacterial vaccine strains, we applied next-generation sequencing to a Clostridium tetani model strain (including inter- and intra-lab replicates) and other strains. Data were processed to determine (gain or loss of) gene copy numbers. Strains could easily be distiguished based on gain/loss of prophage-like and CRISPR/Cas genes. We found that the model strain has multiple copies of the plasmid carrying the gene coding for tetanus toxin as well as several other genes. Data were ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Clostridium tetani Source Type: research
Publication date: Available online 11 February 2020Source: BiologicalsAuthor(s): Jeroen L.A. Pennings, Eric Abachin, Sylvie Uhlrich, Raphaël Esson, Laurent Mallet, Rob J. VandebrielAbstractProduction of tetanus and other clostridial vaccines highly depends on the stable and reproducible production of high toxin levels. This creates a need to ensure the genetic stability of seed strains. We developed a two-stage method for improved assessment of the genetic stability of Clostridium seed strains. This method is based on next-generation sequencing (NGS) of strain DNA and mapping the sequence reads to a reference sequence...
Source: Biologicals - Category: Biology Source Type: research
New guidance allows for either Tdap or Td to be used in situations where Td was previously recommended, including for the 10-year booster and tetanus prophylaxis for wound management.Morbidity &Mortality Weekly Report
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Public Health & Prevention Journal Article Source Type: news
William F. Gilly, Corbin Renken, Joshua J. C. Rosenthal, and William M. Kier An important aspect of the performance of many fast muscle fiber types is rapid excitation. Previous research on the cross-striated muscle fibers responsible for the rapid tentacle strike in squid has revealed the specializations responsible for high shortening velocity, but little is known about excitation of these fibers. Conventional whole-cell patch recordings were made from tentacle fibers and the slower obliquely striated muscle fibers of the arms. The fast-contracting tentacle fibers show an approximately 10-fold greater sodium conductance...
Source: Journal of Experimental Biology - Category: Biology Authors: Tags: RESEARCH ARTICLE Source Type: research
Conclusions: North Dakota health care providers have responded positively to the recommendation of the ACIP to administer a dose of Tdap vaccine to women during each pregnancy and have increased their administration of the vaccine to their patients.
Source: Journal of Public Health Management and Practice - Category: Health Management Tags: Research Reports: Research Full Report Source Type: research
Conclusions: We observed modest associations between live vaccine receipt and non–vaccine-targeted infections. In this observational study, multiple factors, including healthcare-seeking behavior, may have influenced results.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
Abstract Production of tetanus and other clostridial vaccines highly depends on the stable and reproducible production of high toxin levels. This creates a need to ensure the genetic stability of seed strains. We developed a two-stage method for improved assessment of the genetic stability of Clostridium seed strains. This method is based on next-generation sequencing (NGS) of strain DNA and mapping the sequence reads to a reference sequence. The output allows analysis of global genome consistency followed, if necessary, by detailed expert judgement of potential deviations at the gene level. The limit of detection...
Source: Biologicals : Journal of the International Association of Biological Standardization - Category: Biotechnology Authors: Tags: Biologicals Source Type: research
FRIDAY, Feb. 7, 2020 -- The hexavalent combined diphtheria and tetanus toxoids and acellular pertussis (DTaP) adsorbed, inactivated poliovirus (IPV), Haemophilus influenza type b (Hib) conjugate (meningococcal protein conjugate), and hepatitis B...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
This report summarizes the indications for DTaP-IPV-Hib-HepB and provides guidance for its use. PMID: 32027629 [PubMed - indexed for MEDLINE]
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
AbstractCancer is one of the main causes of mortality worldwide and a major public health concern. Among various strategies, therapeutic vaccines have been developed to stimulate anti-tumoral immune responses. However, in spite of extensive studies, this approach suffers from a lack of efficacy. Recently, we designed the MAG-Tn3 vaccine, aiming to induce antibody responses against Tn, a tumor-associated carbohydrate antigen. The Tn antigen is of interest because it is expressed by several adenocarcinomas, but not normal cells. The fully synthetic glycopeptide vaccine MAG-Tn3 is composed of four arms built on three adjacent...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
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