Pharmacokinetic and Pharmacodynamic Characteristics of Subcutaneously Applied PTH-1-37

Conclusions:PTH-1-37 is rapidly absorbed after s.c. injection, has a short plasma elimination half-life, and does not accumulate during multiple dosing. Biological activity was demonstrated by rising serum calcium and decreasing endogenous PTH-1-84 in blood plasma. The study drugs were well tolerated and safe. Our investigation presents data that PTH-1-37 is an excellent drug candidate for intervening with syndromes of dysregulation of calcium metabolism.Kidney Blood Press Res 2016;41:507-518
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research