The Top 5 Nutrients For Healthy Skin
We all want that dewy, youthful glow to our skin and there's no better way to make that happen than to eat a healthy, balanced diet. Our skin's appearance is the first thing people notice and when our skin looks good, we feel good about ourselves. To obtain beautiful skin, it begins from the inside out. Our food choices make a huge difference and when we feed ourselves the nutrients to make this happen, our skin is a reflection of that. Some of our biggest beauty concerns have to do with appearance of aging skin - wrinkles, discoloration, adult acne, and sagging skin. There are many factors that can determine how well our skin ages from genetics, environmental damage and our lifestyle choices. One of the biggest reasons for damage to our skin is a result of oxidation which is the loss of electrons during a reaction by molecules called free radicals which take electrons from healthy cells. Sun damage and cigarette smoking are two of the most damaging oxidative stressors our skin is exposed to. If you've never smoked - good for you but if you currently do so, there is no better time than now to quit smoking for the health of your skin among other reasons. Always wear sunscreen every day to protect skin from damaging UVA and UVB rays. Another lifestyle habit we must embrace if we want to protect our skin is to eat a diet rich in antioxidants. These powerful substances found mostly in fresh fruits and vegetables, help prevent or stop cell damage caused by oxidants. They al...
Sacituzumab, is an antibody that zeroes in on cancer cells. Like a homing missile, it delivers a 'warhead' in the form of a potent chemotherapy drug.
Conclusion: Our case showed good response to primary tumor and gingival metastasis but not to intestinal obstruction. ALK inhibitor often shows high response rate and long survival for ALK rearrangement NSCLC, however ALK rearranged positive NSCLC with gingival metastasis may have poor prognosis.Case Rep Oncol 2019;12:171 –177
ConclusionsWe found no consistent association between pre-chemotherapy PIM defined by STOPP and outcomes.
ConclusionsOur study supports the association between involuntary smoking and the risk of HNC. The association may be stronger for oral cavity cancer than for other HNC subsites.
In this study, we revisited this claim by independently evaluating the proposed marker haplotype using 2 different patient cohorts recruited in different research settings. Meta-analysis of these new postmastectomy cohorts and the original cohort confirmed significant association of the CACNG2 haplotype with PMP. In addition, we tested whether the same markers would predict chronic postsurgical pain in men who underwent surgery for inguinal hernia repair, and whether there is significant genetic association with cutaneous thermal sensitivity in postmastectomy and postherniotomy patients. We found that the biomarker is sele...
In this study, we report that daily treatment with decitabine (2 µg/g, intraperitoneally) attenuated nociceptive behavior in the 4T1-luc2 mouse model of bone cancer pain. We hypothesized that the analgesic mechanism of decitabine involved activation of the endogenous opioid system through demethylation and reexpression of the transcriptionally silenced endothelin B receptor gene, Ednrb. Indeed, Ednrb was hypermethylated and transcriptionally silenced in the mouse model of bone cancer pain. We demonstrated that expression of Ednrb in the cancer cells lead to release of β-endorphin in the cell supernatant, which r...
Our recent work has shown that the early-life administration of vincristine (VNC), commonly used to treat pediatric cancers, evokes mechanical pain hypersensitivity in rats that emerges during adolescence and persists into adulthood. However, the underlying mechanisms remain unclear, as nothing is known about how neonatal VNC treatment influences peripheral and central nociceptive processing at the cellular level. Here, we used in vitro intracellular microelectrode and whole-cell patch-clamp recordings to evaluate the consequences of early-life VNC administration on the intrinsic membrane properties of adolescent dorsal ro...
Conclusion: This research allowed us to identify the epidemiological profiles of the demands of outpatients for dermatologists in various contexts. The results also highlight the importance of aesthetic demands in privately funded consultations and the significance of diseases such as acne, nonmelanoma skin cancer, leprosy, and psoriasis to public health.
CONCLUSION: The treatment of skin diseases based on topical delivery of siRNA, which act by inhibiting the expression of target transcripts, offers many potential therapeutic advantages for suppressing genes into the skin. PMID: 30084329 [PubMed - as supplied by publisher]
(University of Colorado Anschutz Medical Campus) A study published today in JAMA Dermatology combines the prevalence of skin diseases around the world with their likelihood of creating disability across the lifespan to define the following 10 most challenging conditions (arranged in order of decreasing 'disability-adjusted life years'): dermatitis, acne, hives, psoriasis, viral skin diseases, fungal skin diseases, scabies, melanoma, pyoderma, cellulitis, non-melanoma skin cancer, decubitus ulcer, and alopecia areata.
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