Coordinated Emergency Care Saves Lives, Lessens Damage During Heart Attack

Contact: Sarah Avery Phone: 919-660-1306 Email:sarah.avery@duke.eduhttps://www.dukehealth.orgEMBARGOED FOR RELEASE until 4 p.m (ET) on Monday, Aug. 1, 2016DURHAM, N.C. -- Patients suffering from deadly heart attacks can be spared more extensive heart damage when emergency responders and hospitals work together to standardize their treatment processes, according to a study published August 1 in Circulation, a journal of the American Heart Association (AHA).  The findings are based on a national study launched in 2012 by the AHA and Duke Health that focused on ST-segment elevation myocardial infarction (STEMI), a type of heart attack where one of the blood vessels supplying the heart becomes blocked. Without blood flow, the heart muscle can be quickly and irreparably damaged, leading to shock, cardiac arrest and death.  “This work is important because heart attacks are such a common cause of death,” saidChristopher Granger, M.D., senior author of the study who helped lead the national project.“The single most important way to prevent death in the case of heart attack is to rapidly open the blood vessel so that blood flow is restored. This is one of the most important things we can do in all of cardiovascular care,” said Granger, who is also a professor of medicine at Duke University School of Medicine. The 18-month project, called Mission: Lifeline STEMI Systems Accelerator, involved nearly 24,000 patients, 484 hospitals, and 1,253 EMS age...
Source: DukeHealth.org: Duke Health Features - Category: Pediatrics Tags: Duke Medicine Source Type: news

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In this study, we used data mining techniques to search for subtypes in an unbiased fashion. Using electronic signatures of the disease, we identified a cohort of 13,290 patients with NAFLD from a hospital database. We gathered clinical data from multiple sources and applied unsupervised clustering to identify five subtypes among this cohort. Descriptive statistics and survival analysis showed that the subtypes were clinically distinct and were associated with different rates of death, cirrhosis, hepatocellular carcinoma, chronic kidney disease, cardiovascular disease, and myocardial infarction. Novel disease subtypes iden...
Source: Pacific Symposium on Biocomputing - Category: Bioinformatics Tags: Pac Symp Biocomput Source Type: research
CONCLUSIONS: Both low and high Hgb levels were associated with an increased risk of death from various causes, and some diseases showed different patterns according to sex. PMID: 31795616 [PubMed - in process]
Source: Journal of Preventive Medicine and Public Health - Category: International Medicine & Public Health Tags: J Prev Med Public Health Source Type: research
CONCLUSIONS: The validity of self-reported disease was lower than expected, especially in those who reported having been diagnosed with MI. Proper consideration is needed when using these self-reported data in further studies. PMID: 31795614 [PubMed - in process]
Source: Journal of Preventive Medicine and Public Health - Category: International Medicine & Public Health Tags: J Prev Med Public Health Source Type: research
Conclusions: MicroRNA-146a exerts a protective effect against MIRI, which might be partially mediated by the target gene Med1 and related to the apoptosis signalling pathway. PMID: 31798643 [PubMed - in process]
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Tags: Cell Mol Biol Lett Source Type: research
Contributors : German Osmak ; Natalia Baulina ; Philipp Koshkin ; Olga FavorovaSeries Type : Expression profiling by arrayOrganism : Homo sapiensMyocardial infarction (MI) is one of the most severe manifestations of coronary artery disease (CAD) and the leading cause of death from non-infectious diseases worldwide. It is known, that the central component of CAD pathogenesis is a chronic vascular inflammation. However, the mechanisms underlying the changes that occur in T, B and NK-lymphocytes, monocytes and other immune cells during CAD and MI are still poorly understood. One of those pathogenic mechanisms might be the dys...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Conditions:   Acute Myocardial Infarction;   Non-Obstructive Coronary Atherosclerosis;   Ischemic Heart Disease;   Angina Pectoris;   Coronary Microvascular Disease Interventions:   Other: MINOCA registry;   Diagnostic Test: CCTA Phenotypes Sponsor:   AHEPA University Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 5 December 2019Source: Journal of Cardiology CasesAuthor(s): Diego Della Riva, Matteo Bruno, Nevio TaglieriAbstractLarge clinical trials and meta-analyses have shown that thrombus aspiration (TA) in the setting of ST-T segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) does not improve clinical outcome, whilst it may be associated with an increased risk of stroke. Accordingly, in the most recent European Society of Cardiology guidelines the role of routine TA during PPCI has been downgraded to a class III recommendation with level ...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
In conclusion, supraphysiological doses of protein supplements, anabolic steroids, and other nutritional products bear a risk factor for CAD.
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
We report a 75-year-old woman referred for non-ST-elevation myocardial infarction due to prominent Thebesian veins who displayed a perfusion defect in cardiac magnetic resonance imaging.
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
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Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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