Capturing Identity and Fate Ex Vivo: Stem Cells from the Mouse Blastocyst.

Capturing Identity and Fate Ex Vivo: Stem Cells from the Mouse Blastocyst.
Curr Top Dev Biol. 2016;120:361-400
Authors: Garg V, Morgani S, Hadjantonakis AK
Abstract
During mouse preimplantation development, three molecularly, morphologically, and spatially distinct lineages are formed, the embryonic epiblast, the extraembryonic primitive endoderm, and the trophectoderm. Stem cell lines representing each of these lineages have now been derived and can be indefinitely maintained and expanded in culture, providing an unlimited source of material to study the interplay of tissue-specific transcription factors and signaling pathways involved in these fundamental cell fate decisions. Here we outline our current understanding of the derivation, maintenance, and properties of these in vitro stem cell models representing the preimplantation embryonic lineages.
PMID: 27475857 [PubMed - as supplied by publisher]

Source: Current Topics in Developmental Biology - August 1, 2016 Category: Biology Authors: Garg V, Morgani S, Hadjantonakis AK Tags: Curr Top Dev Biol Source Type: research