GSE77824 Multivalent Influenza DNA vaccine induces cross-reactive polyfunctional T lymphocytes and promotes rapid clearance of heterologous challenge strain in non-human primates

Contributors : Merika Koday ; Jolie Leonard ; Michael Koday ; Debra Bratt ; James Fuller ; Robert Murnane ; Todd Reinhart ; Amy Hartman ; Kelly Stefano-Cole ; Adriana Forero ; Juliet Morrison ; Michael Katze ; Deborah FullerSeries Type : Expression profiling by arrayOrganism : Macaca fascicularis ; Macaca mulattaRecent avian and swine-origin influenza virus outbreaks illustrate the ongoing threat of influenza pandemic. New vaccines that offer accelerated production and broader, more universal protection against drifted and shifted strains are needed. Here, we investigated a multivalent PMED DNA vaccine for the ability to induce antibody and T cell responses against four HA antigens, nucleoprotein and the ectodomain of M2 (M2e).
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Macaca fascicularis Macaca mulatta Source Type: research