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Peripheral mRNA expression of pluripotency markers in bipolar disorder and the effect of long-term lithium treatment.

CONCLUSIONS: The overexpression of the pluripotency master transcriptional factors in patients with a long duration of BD not treated with lithium, may contribute to the pathogenesis of the illness and make them potential biological markers of BD. Long-term lithium treatment may attenuate these excessive regenerative processes, especially in relation to the transcription factors Oct-4 and Sox2. PMID: 27472467 [PubMed - as supplied by publisher]
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Tags: Pharmacol Rep Source Type: research

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Authors: Colpo GD, Leboyer M, Dantzer R, Trivedi MH, Teixeira AL Abstract INTRODUCTION: Inflammation seems to play a role in the pathophysiology of mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD). In the last years several studies have shown increased levels of inflammatory and/or immune markers in patients with mood disorders. Accordingly, the immune system has become a target of interest for the development of biomarkers and therapeutics for mood disorders. Areas covered: Here, we review the evidence showing low-grade inflammation in mood disorders and the studies evaluating immun...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Neurogenesis encompasses an entire set of events that leads to the generation of newborn neurons from neural stem cells and more committed progenitor cells, including cell division, the production of migratory precursors and their progeny, differentiation and integration into circuits. In particular, the precise control of neuronal migration and morphological changes is essential for the development of the neocortex. Postmitotic cells within the intermediate zone have been found to transiently assume a characteristic “multipolar” morphology, after which a multipolar‐to‐bipolar transition occurs before the c...
Source: Genes to Cells - Category: Genetics & Stem Cells Authors: Tags: REVIEW ARTICLE Source Type: research
Conclusion Long-term treatment with lithium may suppress the activation of regenerative processes by reducing the number of VSELs circulating in PB. These cells, in BD patients not treated with lithium, may provide a new potential biological marker of the illness and its clinical progress. The higher expression of peripheral mRNA markers in BD patients may involve ongoing inflammatory process, compensatory mechanisms and regenerative responses. Long-term lithium treatment may attenuate these mechanisms, especially in relation to the transcription factors Oct-4, Sox-2, GFAP and Olig1.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
ConclusionsPublished studies have primarily focused on understanding bipolar disorder pathology, but initial work is also being done to use iPS technology for drug discovery. In terms of disease pathology, some evidence is pointing toward a differentiation defect with more ventral cell types being prominent. Additionally, there is evidence for a calcium signaling defect, a finding that builds on the genome‐wide association study results. Continued work with iPS cells will certainly help us understand bipolar disorder and provide a way forward for improved treatments.
Source: Bipolar Disorders - Category: Psychiatry Authors: Tags: REVIEW Source Type: research
AbstractSeveral lines of evidence implicate serotonin in the etiology of multiple psychiatric disorders, especially mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BD). Much of our current understanding of biological mechanisms underlying serotonergic alterations in mood disorders comes from animal studies. Innovation in induced pluripotent stem cell and transdifferentiation technologies for deriving neurons from adult humans has enabled the study of disease-relevant cellular phenotypes in vitro. In this context, human serotonergic neurons can now be generated using three recently published me...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
Publication date: Available online 24 June 2017 Source:Stem Cell Research Author(s): Xi Chen, Shaojun Wang, Haiwei Xu, Joao D. Pereira, Konstantinos E. Hatzistergos, Dieter Saur, Barbara Seidler, Joshua M. Hare, Mark A. Perrella, Zheng Qin Yin, Xiaoli Liu Progress in cell therapy for retinal disorders has been challenging. Recognized retinal progenitors are a heterogeneous population of cells that lack surface markers for the isolation of live cells for clinical implementation. In the present application, our objective was to use the stem cell factor receptor c-Kit (CD117), a surface marker, to isolate and evaluate a dist...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Abstract Research into psychiatric disorders has long been hindered by the lack of appropriate models. Induced pluripotent stem cells (iPSCs) offer an unlimited source of patient‐specific cells, which in principle can be differentiated into all disease‐relevant somatic cell types to create in vitro models of the disorder of interest. Here, neuronal differentiation protocols available for this purpose and the current progress on iPSCs‐based models of schizophrenia, autism spectrum disorders and bipolar disorder were reviewed. We also discuss the impact of the recently developed CRISPR/Cas9 genome editing tool in the d...
Source: Brain Pathology - Category: Neurology Authors: Tags: MINI ‐SYMPOSIUM: USING iPSCs TO UNDERSTAND HUMAN NEUROLOGICAL DISEASE: POTENTIAL AND LIMITATIONS Source Type: research
The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases is generally challenging. However, hiPSCs from BPD patients responsive to lithium offered unique opportunities to discern lithium's target and hence gain molecular insight into BPD. By profiling...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
A major challenge in understanding neuropsychiatric disorders has been the lack of viable cells and tissues to analyze. Patient-derived induced pluripotent stem cells (iPSC) offer the opportunity to examine neural tissues and the prospect of identifying underlying disease mechanisms. We previously reported alterations in ion channel mRNA levels in BD neurons, specifically increased mRNA for the calcium channel gene CACNA1C.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
Bipolar disorder (BD) is a progressive psychiatric disorder with more than 3% prevalence worldwide. Affected individuals experience recurrent episodes of depression and mania, disrupting normal life and increasing the risk of suicide greatly. The complexity and genetic heterogeneity of psychiatric disorders have challenged the development of animal and cellular models. We recently reported that hippocampal dentate gyrus (DG) neurons differentiated from induced pluripotent stem cell (iPSC)-derived fibroblasts of BD patients are electrophysiologically hyperexcitable.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: SYMPOSIUM Source Type: research
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