Peripheral mRNA expression of pluripotency markers in bipolar disorder and the effect of long-term lithium treatment.

CONCLUSIONS: The overexpression of the pluripotency master transcriptional factors in patients with a long duration of BD not treated with lithium, may contribute to the pathogenesis of the illness and make them potential biological markers of BD. Long-term lithium treatment may attenuate these excessive regenerative processes, especially in relation to the transcription factors Oct-4 and Sox2. PMID: 27472467 [PubMed - as supplied by publisher]
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Tags: Pharmacol Rep Source Type: research

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Publication date: Available online 17 September 2018Source: Stem Cell ResearchAuthor(s): Viola Stella Palladino, Nadia Omega Cipta Subrata, Andreas Geburtig-Chiocchetti, Rhiannon McNeill, Per Hoffmann, Andreas Reif, Sarah Kittel-SchneiderAbstractFibroblasts were isolated from skin biopsies from two patients with bipolar I disorder. One patient was a 26 year old female carrying a risk haplotype in the DGKH (diacylglycerol kinase eta) gene and the other was a non-carrier 27 year old male. Patient fibroblasts were reprogrammed into human induced pluripotent stem cells (hiPSCs) by using a Sendai virus vector. DGKH-risk hap...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
ConclusionsAlterations in F-actin polymerization and WRC have been found in a number of genetic subgroups of IDD and ASD. Thus, LS, a very rare genetic condition, is linked to a more expansive family of genes responsible for neurodevelopmental disorders that have shared pathogenic features.
Source: Molecular Autism - Category: Molecular Biology Source Type: research
Publication date: Available online 3 August 2018Source: Seminars in Cancer BiologyAuthor(s): Gwenola Manic, Antonella Sistigu, Francesca Corradi, Martina Musella, Ruggero De Maria, Ilio VitaleAbstractCancer stem cells (CSCs) are subpopulations of multipotent stem cells (SCs) responsible for the initiation, long-term clonal maintenance, growth and spreading of most human neoplasms. Reportedly, CSCs share a very robust DNA damage response (DDR) with embryonic and adult SCs, which allows them to survive endogenous and exogenous genotoxins. A range of experimental evidence indicates that CSCs have high but heterogeneous levels...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: 8 May 2018Source: Stem Cell Reports, Volume 10, Issue 5Author(s): Mekayla A. Storer, Denis Gallagher, Michael P. Fatt, Jaclin V. Simonetta, David R. Kaplan, Freda D. MillerSummaryCirculating systemic factors can regulate adult neural stem cell (NSC) biology, but the identity of these circulating cues is still being defined. Here, we have focused on the cytokine interleukin-6 (IL-6), since increased circulating levels of IL-6 are associated with neural pathologies such as autism and bipolar disorder. We show that IL-6 promotes proliferation of post-natal murine forebrain NSCs and that, when the IL-6 recept...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: October 2018Source: Journal of Chemical Neuroanatomy, Volume 92Author(s): Zohreh Bagher, Seyed Kamran Kamrava, Rafieh Alizadeh, Mohammad Farhadi, Moloud Absalan, Masoumeh Falah, Faezeh Faghihi, Arash Zare-Sadeghi, Ali KomeiliAbstractCell transplantation is a potential therapeutic approach for repairing neuropathological and neurodegenerative disorders of central nervous system by replacing the degenerated cells with new ones. Among a variety of stem cell candidates to provide these new cells, olfactory ectomesenchymal stem cells (OE-MSCs) have attracted a great attention due to their neural crest origin, ...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
Publication date: 8 May 2018Source: Stem Cell Reports, Volume 10, Issue 5Author(s): Mekayla A. Storer, Denis Gallagher, Michael P. Fatt, Jaclin V. Simonetta, David R. Kaplan, Freda D. MillerSummaryCirculating systemic factors can regulate adult neural stem cell (NSC) biology, but the identity of these circulating cues is still being defined. Here, we have focused on the cytokine interleukin-6 (IL-6), since increased circulating levels of IL-6 are associated with neural pathologies such as autism and bipolar disorder. We show that IL-6 promotes proliferation of post-natal murine forebrain NSCs and that, when the IL-6 recept...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: October 2018Source: Journal of Chemical Neuroanatomy, Volume 92Author(s): Zohreh Bagher, Seyed Kamran Kamrava, Rafieh Alizadeh, Mohammad Farhadi, Moloud Absalan, Masoumeh Falah, Faezeh Faghihi, Arash Zare-Sadeghi, Ali KomeiliAbstractCell transplantation is a potential therapeutic approach for repairing neuropathological and neurodegenerative disorders of central nervous system by replacing the degenerated cells with new ones. Among a variety of stem cell candidates to provide these new cells, olfactory ectomesenchymal stem cells (OE-MSCs) have attracted a great attention due to their neural crest origin, ...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
Publication date: Available online 25 May 2018 Source:Journal of Chemical Neuroanatomy Author(s): Zohreh Bagher, Seyed Kamran Kamrava, Rafieh Alizadeh, Mohammad Farhadi, Mahta Absalan, Masoumeh Falah, Faezeh Faghihi, Arash Zare-Sadegh, Ali Komeili Cell transplantation is a potential therapeutic approach for repairing neuropathological and neurodegenerative disorders of central nervous system by replacing the degenerated cells with new ones. Among a variety of stem cell candidates to provide these new cells, olfactory ectomesenchymal stem cells (OE-MSCs) have attracted a great attention due to their neural crest origin, ea...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
Condition:   Treatment-resistant Bipolar Depression Interventions:   Biological: Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs);   Biological: Placebo Sponsor:   The University of Texas Health Science Center, Houston Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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