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Peripheral mRNA expression of pluripotency markers in bipolar disorder and the effect of long-term lithium treatment.

CONCLUSIONS: The overexpression of the pluripotency master transcriptional factors in patients with a long duration of BD not treated with lithium, may contribute to the pathogenesis of the illness and make them potential biological markers of BD. Long-term lithium treatment may attenuate these excessive regenerative processes, especially in relation to the transcription factors Oct-4 and Sox2. PMID: 27472467 [PubMed - as supplied by publisher]
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Tags: Pharmacol Rep Source Type: research

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Condition:   Treatment-resistant Bipolar Depression Interventions:   Biological: Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs);   Biological: Placebo Sponsor:   The University of Texas Health Science Center, Houston Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Happy Saturday, Psych Central readers! This week’s Psychology Around the Net takes a look at the new 3-D mini-brains researchers are using to better study the connection between severe mental illnesses, how we can make insecurity work for us (yes, you read that correctly), studies that take a closer look at mental health challenges LGBTQ youth face, and more. 3-D ‘Mini-Brains’ Shed Light On Mental Illness: Some mental illnesses such as severe depression, bipolar disorder, and schizophrenia share a common genetic link, and now researchers have used human stem cells to create a 3-D model of the brain to be...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Bullying Children and Teens Psychiatry Psychology Around the Net Research Sexuality 3-D brain Bisexual bright side Gay Hattie Gladwell human stem cells insecure Lesbian LGBTQ Mental Health Care Mental I Source Type: blogs
The study of psychiatric disorders was limited by the paucity of adequate models. These disorders are genetically complex, with many candidate-associated genes. Due to this genetic complexity, animal models that were developed did not recapitulate most of the phenotypes associated with the disorders. The introduction of induced pluripotent stem cells (iPSCs) allowed measurement of cellular phenotypes for psychiatric disorders.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
The granule cell layer of the Dentate Gyrus (DG-GCL) is an unusually homogeneous cell population. Previous findings linking this important cell type to bipolar disorder and schizophrenia used animal models, induced pluripotent stem cell (iPSC), or low-resolution functional imaging. We therefore sought to isolate and characterize human DG-GCL neurons to better characterize their role in psychiatric disorders.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: SYMPOSIUM Source Type: research
Bipolar disorder (BP) is a complex neuropsychiatric disorder associated with episodes of altered mood, energy, and sleep. The molecular and cellular mechanisms of BP are poorly understood. Patient-derived induced pluripotent stem cells (iPSC) provide a model for studying neurodevelopment in BP, which may help uncover disease mechanisms.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
In this report, Storer and colleagues demonstrate that the circulating cytokine IL-6, which is elevated in humans in different pathological situations, can perturb neural stem cell biology after birth. They show that IL-6 signaling is essential for self-renewal and maintenance of post-natal and adult NSCs in the murine forebrain under normal homeostatic conditions.
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Contributors : Lu Wang ; Daniel Hiler ; Beisi Xu ; Issam Aldiri ; Xiang Chen ; Lyra Griffiths ; Marc Valentine ; Abbas Shirinifard ; Andras Sablauer ; Suresh Thiagarajan ; Marie-Elizabeth Barabas ; Jiakun Zhang ; Dianna Johnson ; Sharon Frase ; Michael A DyerSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusDiverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3 and Myc. Many of these induced pluripotent stem cells (iPSCs) retain an epigenetic memory of their cellular origins and this in turn may bias their subsequent differ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Lu Wang ; Daniel Hiler ; Beisi Xu ; Issam Aldiri ; Xiang Chen ; Lyra Griffiths ; Marc Valentine ; Abbas Shirinifard ; Andras Sablauer ; Suresh Thiagarajan ; Marie-Elizabeth Barabas ; Jiakun Zhang ; Dianna Johnson ; Sharon Frase ; Michael A DyerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDiverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3 and Myc. Many of these induced pluripotent stem cells (iPSCs) retain an epigenetic memory of their cellular origins and this in turn may bias their subsequent differe...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Lu Wang ; Daniel Hiler ; Beisi Xu ; Issam Aldiri ; Xiang Chen ; Lyra Griffiths ; Marc Valentine ; Abbas Shirinifard ; Andras Sablauer ; Suresh Thiagarajan ; Marie-Elizabeth Barabas ; Jiakun Zhang ; Dianna Johnson ; Sharon Frase ; Michael A DyerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDiverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3 and Myc. Many of these induced pluripotent stem cells (iPSCs) retain an epigenetic memory of their cellular origins and this in turn may bias their subs...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
Authors: Colpo GD, Leboyer M, Dantzer R, Trivedi MH, Teixeira AL Abstract INTRODUCTION: Inflammation seems to play a role in the pathophysiology of mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD). In the last years several studies have shown increased levels of inflammatory and/or immune markers in patients with mood disorders. Accordingly, the immune system has become a target of interest for the development of biomarkers and therapeutics for mood disorders. Areas covered: Here, we review the evidence showing low-grade inflammation in mood disorders and the studies evaluating immun...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
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