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Peripheral mRNA expression of pluripotency markers in bipolar disorder and the effect of long-term lithium treatment.

CONCLUSIONS: The overexpression of the pluripotency master transcriptional factors in patients with a long duration of BD not treated with lithium, may contribute to the pathogenesis of the illness and make them potential biological markers of BD. Long-term lithium treatment may attenuate these excessive regenerative processes, especially in relation to the transcription factors Oct-4 and Sox2. PMID: 27472467 [PubMed - as supplied by publisher]
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Tags: Pharmacol Rep Source Type: research

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Conclusion Long-term treatment with lithium may suppress the activation of regenerative processes by reducing the number of VSELs circulating in PB. These cells, in BD patients not treated with lithium, may provide a new potential biological marker of the illness and its clinical progress. The higher expression of peripheral mRNA markers in BD patients may involve ongoing inflammatory process, compensatory mechanisms and regenerative responses. Long-term lithium treatment may attenuate these mechanisms, especially in relation to the transcription factors Oct-4, Sox-2, GFAP and Olig1.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
AbstractSeveral lines of evidence implicate serotonin in the etiology of multiple psychiatric disorders, especially mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BD). Much of our current understanding of biological mechanisms underlying serotonergic alterations in mood disorders comes from animal studies. Innovation in induced pluripotent stem cell and transdifferentiation technologies for deriving neurons from adult humans has enabled the study of disease-relevant cellular phenotypes in vitro. In this context, human serotonergic neurons can now be generated using three recently published me...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
Publication date: Available online 24 June 2017 Source:Stem Cell Research Author(s): Xi Chen, Shaojun Wang, Haiwei Xu, Joao D. Pereira, Konstantinos E. Hatzistergos, Dieter Saur, Barbara Seidler, Joshua M. Hare, Mark A. Perrella, Zheng Qin Yin, Xiaoli Liu Progress in cell therapy for retinal disorders has been challenging. Recognized retinal progenitors are a heterogeneous population of cells that lack surface markers for the isolation of live cells for clinical implementation. In the present application, our objective was to use the stem cell factor receptor c-Kit (CD117), a surface marker, to isolate and evaluate a dist...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Abstract Research into psychiatric disorders has long been hindered by the lack of appropriate models. Induced pluripotent stem cells (iPSCs) offer an unlimited source of patient‐specific cells, which in principle can be differentiated into all disease‐relevant somatic cell types to create in vitro models of the disorder of interest. Here, neuronal differentiation protocols available for this purpose and the current progress on iPSCs‐based models of schizophrenia, autism spectrum disorders and bipolar disorder were reviewed. We also discuss the impact of the recently developed CRISPR/Cas9 genome editing tool in the d...
Source: Brain Pathology - Category: Neurology Authors: Tags: MINI ‐SYMPOSIUM: USING iPSCs TO UNDERSTAND HUMAN NEUROLOGICAL DISEASE: POTENTIAL AND LIMITATIONS Source Type: research
The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases is generally challenging. However, hiPSCs from BPD patients responsive to lithium offered unique opportunities to discern lithium's target and hence gain molecular insight into BPD. By profiling...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
A major challenge in understanding neuropsychiatric disorders has been the lack of viable cells and tissues to analyze. Patient-derived induced pluripotent stem cells (iPSC) offer the opportunity to examine neural tissues and the prospect of identifying underlying disease mechanisms. We previously reported alterations in ion channel mRNA levels in BD neurons, specifically increased mRNA for the calcium channel gene CACNA1C.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
Bipolar disorder (BD) is a progressive psychiatric disorder with more than 3% prevalence worldwide. Affected individuals experience recurrent episodes of depression and mania, disrupting normal life and increasing the risk of suicide greatly. The complexity and genetic heterogeneity of psychiatric disorders have challenged the development of animal and cellular models. We recently reported that hippocampal dentate gyrus (DG) neurons differentiated from induced pluripotent stem cell (iPSC)-derived fibroblasts of BD patients are electrophysiologically hyperexcitable.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: SYMPOSIUM Source Type: research
Induced pluripotent stem cell (iPSC) technology has enabled the derivation of human neural progenitor cells (NPCs) that display circadian rhythms. Patient-derived NPCs may model some of the circadian disturbances that often underlie bipolar disorder (BD) and other mood disorders, but are difficult to study in humans. Using NPCs derived from a patient with BD and a healthy control, we investigated cyclic expression patterns of several genes known to participate in the canonical mammalian clock system.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
Authors: McIntyre RS, Johe K, Rong C, Lee Y Abstract INTRODUCTION: Alterations in neurogenic and neurotrophic processes as well as intracellular signalling cascades provides the basis for hypothesizing that neurogenic agents may be therapeutic across multiple RDoC-defined domains (e.g. positive valence systems, general cognitive processes). Moreover, using the DSM-5 taxonomy, neurogenic agents may mitigate symptoms in adults with depressive and bipolar disorders as well as individuals with cognitive disorders. Areas Covered: NSI-189 is a benzylpiperizine-aminiopyridine, a novel chemical entity that stimulates neuro...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Galluzzi et  al. discuss the molecular mechanisms, pathophysiological implications, and therapeutic relevance of the pathways through which embryonic, adult, inducible pluripotent, and cancer stem cells cope with DNA damage.
Source: Molecular Cell - Category: Cytology Authors: Tags: Review Source Type: research
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