Tracking How HIV Disrupts Immune System Informs Vaccine Development

Contact: Samiha Khanna Phone: 919-419-5069 Email: samiha.khanna@duke.edu https://www.dukehealth.org EMBARGOED FOR RELEASE until 2 p.m. (ET) on Friday, July 29, 2016 DURHAM, N.C. -- One of the main mysteries confounding development of an HIV vaccine is why some people infected with the virus make the desired antibodies after several years, but a vaccine can ’t seem to induce the same response. A research team led by scientists at the Duke Human Vaccine Institute has been unraveling that mystery, detailing new insights in a study published July 29 in the journal Science Immunology. Studying 100 HIV-infected people -- half whose immune systems eventually made antibodies capable of broadly neutralizing the virus and half whose immune systems did not -- the researchers found several key immune differences that should help in the development of a how-to manual for an effective vaccine.   “This work gives us the beginning of an understanding of the immune mechanisms that control development of broadly neutralizing antibodies, which is a major goal of a successful HIV vaccine,” said Barton F. Haynes , M.D., director of the Duke Human Vaccine Institute and senior author of the study. “This moves forward important concepts for vaccine design to overcome a roadblock that has been present since we began this work 30 years ago.” In earlier work, Haynes and colleagues studied a person with both HIV and a form of lupus erythematosus, which is...
Source: DukeHealth.org: Duke Health Features - Category: Pediatrics Tags: Duke Medicine Source Type: news

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Publication date: Available online 13 December 2019Source: Brain, Behavior, and ImmunityAuthor(s): N.B. Teixeira, M.B. Sant'Anna, A.C. Giardini, L.P. Araujo, L.A. Fonseca, A.S. Basso, Y. Cury, G. PicoloAbstractMultiple sclerosis (MS) is a Central Nervous System inflammatory demyelinating disease that has as primary symptoms losses of sensory and motor functions, including chronic pain. To date, however, few studies have investigated the mechanisms of chronic pain in animal models of MS since locomotor impairments render difficult its evaluation. It was previously demonstrated that in the MOG35-55-induced EAE, an animal mod...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: 14–20 December 2019Source: The Lancet, Volume 394, Issue 10215Author(s): Annelies Wilder-Smith, Stefan Flasche, Peter G Smith
Source: The Lancet - Category: General Medicine Source Type: research
ConclusionThe present study reports a variant subgroup GII-a PEDV HM2017 strain in China and characterize its pathogenicity. PEDV strain HM2017 of subgroup GII-a presents a promising vaccine candidate for the control of PED outbreaks in China.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In this study H. pylori CagL gene was cloned in pAMJ2008 vector and transferred to Lactococcus lactis MG1363 as the host for CagL antigen production. This recombinant bacterium was orally subjected to mice, and the immune response to CagL was evaluated by ELISA. Intracellular expression of CagL protein was confirmed by Western blot analysis. Mucosal immunization of mice with the recombinant L. lactis significantly stimulated CagL-Specific antibodies: IgA, IgG, cytokine IL-17 and IN-γ. Moreover, the specific anti-CagL IgA response was detected in the feces of immunized mice. These results indicate that CagL of H. pylo...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionsThis study provides initial perspectives on measles preparedness among Idaho CAHs, despite limited generalizability. Future studies should explore whether self-reported preparedness measures reflect the ability of the CAHs to control measles spread when cases present for care.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
A financially troubled Seattle research institute cut back programs, leaving researchers to find new homes for work on infectious diseases like tuberculosis and leprosy.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Infectious Disease Research Institute Vaccination and Immunization Tuberculosis Philanthropy Nonprofit Organizations Drugs (Pharmaceuticals) Leprosy (Hansen ' s Disease) Leishmaniasis Layoffs and Job Reductions Seattle (Wash) your- Source Type: news
Publication date: Available online 12 December 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Sriram Gubbi, Fady Hannah-Shmouni, Joseph G. Verbalis, Christian A. KochAbstractHypophysitis is a heterogeneous condition that leads to inflammation of the sella and/or suprasellar region, potentially resulting in hormonal deficiencies and/or mass effects. A preponderance of hypophysitis subtypes have an underlying autoimmune aetiology. The overall incidence and prevalence of hypophysitis has dramatically increased over the past decade, mainly due to increased awareness of the condition in...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Purpose of review: Overview of neuroendocrine neoplasms in the context of their associations with primary and secondary immunodeficiency states. Recent findings: Malignancies of neuroendocrine origin are well known to be associated with hereditary syndromes, including multiple endocrine neoplasia type 1, von Hippel–Lindau syndrome, neurofibromatosis type 1, and tuberous sclerosis. This review includes the X-linked form of hyper-IgM syndrome (XHIGM), due to mutations in the CD40Ligand gene (CD40LG), as an additional inherited disorder with susceptibility to such malignancies, and discusses neuroendocrine tumors (NETs...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: PRIMARY IMMUNE DEFICIENCY DISEASE: Edited by Stephen Jolles and M. Teresa de la Morena Source Type: research
Conclusions PLWHA had higher risks of incident Sjo╠łgren syndrome, psoriasis, SLE, autoimmune haemolytic anaemia and uveitis.
Source: Annals of the Rheumatic Diseases - Category: Rheumatology Authors: Tags: Immunology (including allergy), Muscle disease, Ophthalmology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Systemic lupus erythematosus Clinical and epidemiological research Source Type: research
Resumo As imunodeficiências primárias (IDP) representam um grupo heterogêneo de doenças resultantes de defeitos hereditários no desenvolvimento, na maturação e na função normal de células do sistema imunológico; assim, tornam os indivíduos suscetíveis a infecções recorrentes, alergia, autoimunidade e doenças malignas. Neste estudo retrospectivo descrevem-se doenças autoimunes (DAI), em especial o lúpus eritematoso sistêmico (LES), que surgiram associadas ao curso das IDP. Classicamente, a litera...
Source: Revista Brasileira de Reumatologia - Category: Rheumatology Source Type: research
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