Targeting mTOR signaling by polyphenols: a new therapeutic target for ageing.

Targeting mTOR signaling by polyphenols: a new therapeutic target for ageing.
Ageing Res Rev. 2016 Jul 21;
Authors: Pazoki-Toroudi H, Amani H, Ajami M, Nabavi SF, Braidy N, Devi KP, Nabavi SM
Abstract
Current aging research is aimed not only at the promotion of longevity, but also at improving ‎health span‎ through the‎ discovery and development‎ of new therapeutic strategies‎‏‎ by investigating ‎molecular and ‎cellular ‎pathways involved in cellular senescence.‎ Understanding the mechanism of action ‎of ‎polyphenolic compounds targeting mTOR (mechanistic target of rapamycin) and related pathways opens up new directions ‎‎to revolutionize ways to slow down the ‎onset and development of age-dependent degeneration. Herein, we will ‎discuss the mechanisms by which polyphenols can delay the‎ molecular ‎pathogenesis of ageing via manipulation or more specifically inhibition of mTOR-signaling pathways. We will also discuss the implications of polyphenols in targeting mTOR and its related ‎pathways‎‎ on ‎health life span extension and longevity.‎.
PMID: 27453478 [PubMed - as supplied by publisher]

Source: Ageing Research Reviews - July 20, 2016 Category: Genetics & Stem Cells Authors: Pazoki-Toroudi H, Amani H, Ajami M, Nabavi SF, Braidy N, Devi KP, Nabavi SM Tags: Ageing Res Rev Source Type: research