Delivery of Topical Therapies.

The objective of this review article is to describe the evidence for the most common topical sinonasal delivery techniques. Evidence supports that high-volume irrigations provide the most reliable delivery of medical therapy to the paranasal sinuses. Low-volume nasal sprays and drops provide reliable delivery to the nasal cavity and a degree of penetration into the middle meatus and olfactory cleft; however, they do not reliably penetrate the paranasal sinuses. Sinus surgery and the head down-forward position optimize the delivery of high-volume irrigations into the paranasal sinuses. Additionally, high-volume irrigations assist in overcoming unfavorable nasal anatomy such as septal deviation and turbinate hypertrophy.
PMID: 27466853 [PubMed - as supplied by publisher]

Source: Advances in Oto-Rhino-Laryngology - July 29, 2016 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research