Pleiotropic effects of statins in the diseases of the liver.
Pleiotropic effects of statins in the diseases of the liver.
World J Gastroenterol. 2016 Jul 21;22(27):6201-6213
Authors: Janicko M, Drazilova S, Pella D, Fedacko J, Jarcuska P
Abstract
Statins are a class of molecules that inhibit HMG CoA reductase. They are usually prescribed as a lipid lowering medication. However, there is accumulating evidence that statins have multiple secondary effects both related and unrelated to their lipid-lowering effect. This narrative review of the literature aims to provide the reader with information from clinical studies related to the effect of statin and statins' potential use in patients with liver diseases. In patients with advanced liver disease due to any etiology, statins exhibit an antifibrotic effect possibly through the prevention of hepatic sinusoidal microthrombosis. Two randomized controlled trials confirmed that statins decrease hepatic vein pressure gradient in patients with portal hypertension and improve the survival of patients after variceal bleeding. Lower rates of infections were observed in patients with cirrhosis who received statin treatment. Statins decrease the risk of hepatocellular carcinoma (HCC) in patients with advanced liver disease in general but particularly in patients with chronic hepatitis B and C. Statins in patients with chronic hepatitis C likely increase the virological response to the treatment with pegylated interferon and ribavirin and have the potential to...
Source: World Journal of Gastroenterology - Category: Gastroenterology Authors: Janicko M, Drazilova S, Pella D, Fedacko J, Jarcuska P Tags: World J Gastroenterol Source Type: research
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