The Endothelium-Dependent Nitric Oxide-cGMP Pathway.

In conclusion, the discovery of the NO-cGMP pathway revolutionized the comprehension of pathophysiological mechanisms involved in cardiovascular and other diseases. However, considering the expression "from bench to bedside" the therapeutic alternatives targeting NO-cGMP did not immediately follow the marked biochemical and pathophysiological revolution. Some therapeutic options have been effective and released on the market for pulmonary hypertension and erectile dysfunction such as inhaled NO, PDE5 inhibitors, and recently sGC stimulators. The therapeutic armamentarium for many other disorders is expected in the near future. There are currently numerous active basic and clinical research programs in universities and industries attempting to develop novel therapies for many diseases and medical applications. PMID: 27451093 [PubMed - in process]
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research

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ConclusionAcute organophosphate poisoning treated with atropine showed a potential for inducing prothrombotic coagulation abnormalities, presented with PT. This life-threatening complication may additionally contribute to prolonged morbidity and mortality in OP poisonings, especially in patients with medical history of comorbidites.
Source: Toxicology Reports - Category: Toxicology Source Type: research
A 71-year-old with Stanford type B aortic dissection treated with Cook Medical (Bloomington, IN) ProForm ™ stent grafts 3 years previously was referred to the nephrology outpatient clinic for asymptomatic new-onset renal impairment. Other comorbidities were chronic hepatitis B, diabetes mellitus, and hypertension. Clinic blood pressure was 152/80 mm Hg, but physical examination was otherwise unremar kable. Serum creatinine was 142 μmol/l, urine protein-to-creatinine ratio 4.07 g/g, and glomerular hematuria was present (210 red cells) without pyuria on urine microscopy.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
The hypothesis that prenatal exposure to poor maternal health or nutrition is a risk factor for adult-onset disease was first proposed by the epidemiologist David Barker in 1990, based on observations in a cohort of low birth weight infants followed into adulthood. Fetal programming is now accepted as an important contributor to the development of cardiovascular disease and other adult conditions. Although the mechanisms remain unknown, it is increasingly assumed that epigenetic mechanisms play a key role in fetal programming.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Digest Source Type: research
A 59-year-old African woman was admitted with generalized weakness. The history consisted of hypertension, which was treated with lisinopril and nifedipine for many years. She denied any use of nonsteroidal anti-inflammatory drugs, herbal medications, or illicit drugs. Physical examination revealed normal vital signs, dry mucous membranes, and no evidence of lymphadenopathy, salivary gland enlargement, or rash. Laboratory evaluation revealed a serum creatinine level of 12.9 mg/dl and a blood urea nitrogen level of 149 mg/dl (baseline, 1.1 and 23 mg/dl, respectively, 3 months ago), a hemoglobin level of 8.2 g/dl, a platelet...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
Hypertension is the largest preventable contributor to worldwide morbidity and  mortality, and improved understanding of hypertension pathophysiology could lead to major therapeutic advances with major societal benefits.1 Blood pressure is defined by the pressure of circulating blood on the vessel wall, determined by the complex relationship between cardiac output, vascular r esistance, and vascular compliance. Hypertension can contribute to or accelerate many cardiovascular diseases including kidney disease, or it may be a consequence of diseases of the regulatory systems.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Controversies in Nephrology Source Type: research
Authors: Muthyala T, Rathore A, Shahnaz G, Kumar D, Singh P, Bhasin S PMID: 31210086 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
Authors: Calzada M, López N, Noguera JA, Mendiola J, Hernández AI, Corbalán S, Sanchez M, Torres AM Abstract Serum Anti-Müllerian hormone (AMH) level could be useful for the diagnosis of polycystic ovary syndrome (PCOS). We evaluated the hormonal status in women for the diagnosis of PCOS. A total of 77 PCOS women and 106 healthy women were enrolled in this study. Serum AMH, gonadotropins [luteinising hormone (LH) and follicle-stimulating hormone (FSH)], oestradiol, testosterone (total and free), 4-androstenedione (ANDST), dehydroepiandrosterone sulphate, sex hormone binding globulin (SHBG)...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
Conclusion: Plasma concentrations of E2 and Ang II decreased after delivery. The plasma concentrations of E2 and Ang II were correlated with each other. PMID: 31204528 [PubMed - as supplied by publisher]
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
Conclusion This evidence supports the need for specific nutritional guidelines for gestational hypertensive disorders, as well as great public attention for overweight women in the fertile age.Resumo Objetivo Diferentes ambientes intrauterinos podem influenciar a varia ção de peso corporal pré-gestacional materno até 6 meses pós-parto. O objetivo do presente estudo foi verificar a associação de fatores sociodemográficos, obstétricos, nutricionais e comportamentais com a variação de peso em mulheres divididas em quatro grupos: hipertensas (HM), dia...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
Abstract The hypothesis of fetal origins to adult diseases proposes that metabolic chronic disorders, including cardiovascular diseases, diabetes, and hypertension originate in the developmental plasticity due to intrauterine insults. These processes involve an adaptative response by the fetus to changes in the environmental signals, which can promote the reset of hormones and of the metabolism to establish a “ thrifty phenotype ” . Metabolic alterations during intrauterine growth restriction can modify the fetal programming. The present nonsystematic review intended to summarize historical and current referenc...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
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