Researchers at Nationwide Children's Hospital describe new type of cancer therapy

( Nationwide Children's Hospital ) A study conducted at Nationwide Children's Hospital has found that a new chemotherapy is effective against both pediatric and adult cancers, and that it allows other chemotherapies to more readily reach their targets.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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In conclusion, our results show that the effect of paclitaxel and oxaliplatin on the structural plasticity of DRG is retained ex vivo (for at least 30 days) and suggest the use of DRG explants derived from chemotherapy-treated mice as an efficient method to investigate the mechanisms underlying CIPN and test for possible therapeutic targets.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
This article mainly opted advance nanotherapy methods, based on most recent studies. Result and conclusion- Nanotechnology provides new molecular contrasts agents and materials to enable earlier and more accurate initial diagnosis, as well as continual monitoring of patient while cancer treatment. This review concludes that nanotechnology as nanodrugs, nano carrier, nanoparticles in combination with radiological methods have a better future in cancer treatment. In this paper, several diagrammatic pathways presented the opted studies and proposed conclusion. PMID: 30426890 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
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Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
ConclusionThis review provided a comprehensive examination of available options for children who have OM. The results support the possibility of a positive effect of palifermin on reducing OM in children receiving cancer therapy.
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Tags: REVIEW Source Type: research
Abstract Reducing the adverse effects of chemotherapy on normal cells such as endothelial cells is a determinant factor of treatment success especially in pregnant women. In this regard, modulatory effect of L-arginine on various cancers is still a controversial topic in cancer therapy. So, this study aimed to compare the effect of L-arginine treatment alone and in combination with 5-fluorouracil (5-FU) on the survival and angiogenesis of primary human umbilical vein endothelial cells (HUVECs) and the breast cancer cell line of MDA-MB-468. Combinations of L-arginine and 5-FU increased cell survival in HUVECs but i...
Source: Food and Chemical Toxicology - Category: Food Science Authors: Tags: Food Chem Toxicol Source Type: research
ConclusionsFindings from this study highlight that real-world experience of docetaxel may differ from that observed in clinical trials and that care must be taken to ensure that treatment options are tailored to the needs of individual patients to promote not only how long patients survive but also the quality of that survival.FundingJanssen
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
ConclusionApplication of cytostatic drugs in combination with adaptogenic plant extracts induced significant changes in transcriptome-wide microarray profiles of neuroglial cells. These changes indicate on potential beneficial effects of adaptogens on FEC induced adverse events in cancer chemotherapy.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Oral and pharyngeal cancer is the most common malignant human cancers. Chemotherapy is an effective approach for anti-oral cancer therapy, while the drug tolerance and resistance remain a problem for oral canc...
Source: BMC Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Tags: Research article Source Type: research
Publication date: January 2019Source: Biomedicine &Pharmacotherapy, Volume 109Author(s): Xin Zhang, Kaikai Ding, Jian Wang, Xingang Li, Peng ZhaoAbstractGlioblastoma multiforme (GBM) is the most common and aggressive primary human brain tumor. Although comprehensive therapies combining radiotherapy and chemotherapy after surgery can prolong survival, the prognosis is still poor with a median survival of only 14.6 months. Chemoresistance is one of the major causes of relapse as well as poor survival in glioma patients. Therefore, novel strategies to overcome chemoresistance are desperately needed for improved treatment ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 30 October 2018Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Hongchao Ma, Shuo Li, Hao Zhang, Yanhui Wei, Lei JiangAbstractThe combined therapeutic strategy have aroused significant interest in cancer therapy due to its enhanced treatment efficacy and reduced side effects. This paper describes the combined chemo- and photothermal therapy of cancer based on PDA@(PDDA-ADA)3-Dox nanocomposites. Polydopamine (PDA) serves not only as photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a core material to...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
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