Measuring Access to Information and Technology: Environmental Factors Affecting Persons With Neurologic Disorders

To develop and validate a patient-reported measure of access to information and technology (AIT) for persons with spinal cord injury, stroke, or traumatic brain injury.
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Tags: Original research Source Type: research

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We describe our planned development efforts to build advanced analytic tools to guide home-based rehabilitation and our proposed randomized trial to evaluate effectiveness and implementation of this approach.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Concept Paper Source Type: research
The determinants of cardiac output (CO) during exercise, i.e., stroke volume (SV) and heart rate (HR), could differ in Paralympic athletes (PAthl) with spinal cord injury (SCI) with respect to PAthl with locomotor impairments caused by different health conditions (HC). The purposes of the present study were the comparisons of two groups of PAthl, one with SCI and one with either amputation (AMP) or post poliomyelitis syndrome (PM), assessing the: (1) peak cardiorespiratory responses and determinants (SV and HR) of CO during maximal and submaximal arm cranking exercise (ACE), respectively; (2) correlations between peak oxyg...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
CONCLUSIONS: We are the first to demonstrate the consistent production of cell-derived, yet cell-free secretome as a biological medicinal product. The results from this study provide the basis for selecting appropriate quality control parameters for GMP-compliant production of therapeutic cell secretomes and pave the way for future clinical trials employing secretomes in tissue regenerative medicine. PMID: 31900195 [PubMed - in process]
Source: Cell Research - Category: Cytology Authors: Tags: Stem Cell Res Ther Source Type: research
cute;csei L Abstract Neuropathic pain is a chronic secondary pain condition, which is a consequence of peripheral or central nervous (somatosensory) system lesions or diseases. It is a devastating condition, which affects around 7% of the general population. Numerous etiological factors contribute to the development of chronic neuropathic pain. It can originate from the peripheral part of the nervous system such as in the case of trigeminal or postherpetic neuralgia, peripheral nerve injury, painful polyneuropathies, or radiculopathies. Central chronic neuropathic pain can develop as a result of spinal cord or bra...
Source: Behavioural Neurology - Category: Neurology Authors: Tags: Behav Neurol Source Type: research
This report discusses how a number of currently incurable diseases might be treated by advances developed as the result of current ongoing research on monkeys. The diseases discussed include Parkinson's disease, amyotrophic lateral sclerosis, spinal cord injury, peripheral neuropathy, and stroke. Finally, the report discusses the devastating effect the animal...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Arthur M. Sackler Colloquium Using Monkey Models to Understand and Develop Treatments for Human Brai Arthur M. Sackler Colloquium Using Monkey Models to Understand and Develop Treatments for Human Brain Disorders Source Type: research
Conclusions This article highlights the important issues about the sEMG control method and accentuates the weaknesses associated with this type of control to assist researchers in overcoming problems that impede sEMG-controlled robotic devices to be feasible and practical tools for people afflicted with hand impairment.
Source: JPO Journal of Prosthetics and Orthotics - Category: Orthopaedics Tags: CME ARTICLES Source Type: research
Abstract Neurologic conditions such as stroke and traumatic brain injury are challenging conditions to study in humans. Animal models are necessary to uncover disease processes and develop novel therapies. When attempting to model these or other neurologic diseases, the accompanying anesthesia and analgesia create variables that are not part of the onset of the clinical disease in the human population but are critical components of the postinjury care both in humans and animals. To maximize model validity, researchers must consider whether the disease process or a novel therapy is being studied. Damage to the neur...
Source: Comparative Medicine - Category: Zoology Authors: Tags: Comp Med Source Type: research
This study aimed to describe experience of a specific protocol for endovascular aortic repair in patients with MFS. METHODS: All MFS patients treated by aortic endovascular repair between February 2015 and August 2018 were included prospectively. The following rules were applied: (i) excluding stent grafts with bare stents and barbs, (ii) proximal landing in a pre-existing graft, or (iii) minimising proximal oversizing when landing in the proximal native aorta (
Source: PubMed: Eur J Vasc Endovasc ... - Category: Surgery Authors: Tags: Eur J Vasc Endovasc Surg Source Type: research
Discussion: The collective findings suggest that large amounts of task-specific (ie, locomotor) practice may be critical for improvements in walking function, although only at higher cardiovascular intensities or with augmented feedback to increase patient's engagement. Lower-intensity walking interventions or impairment-based training strategies demonstrated equivocal or limited efficacy. Limitations: As walking speed and distance were primary outcomes, the research participants included in the studies walked without substantial physical assistance. This guideline may not apply to patients with limited ambulatory fun...
Source: Journal of Neurologic Physical Therapy - Category: Physiotherapy Tags: Clinical Practice Guidelines Source Type: research
(University of California - San Diego) In a UC San Diego study, rats with spinal cord injuries experienced a three-fold increase in motor activity when treated with neural progenitor cells that had been pre-conditioned with a modified form of tPA, a drug commonly used to treat non-hemorrhagic stroke.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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