Speckle tracking determination of mitral tissue annular displacement: comparison with strain and ejection fraction, and association with outcomes in haemodialysis patients

This study aims to compare TMAD with GLS and LVEF and its association with outcomes in haemodialysis patients. 198 haemodialysis patients (median age 64.2  years, 69 % men) had 2D echocardiography, with STE determined GLS and TMAD. Bland–Altman analysis and linear regression assessed relationship between GLS, LVEF and TMAD. Cox regression analysis investigated association of TMAD with mortality and cardiac events. TMAD had low inter- and intra-ob server variability with small biases and narrow limits of agreement (LOA) (bias of −0.01 ± 1.32 (95 % LOA was −2.60 to 2.58) and −0.07 ± 1.27 (95 % LOA −2.55 to 2.41) respectively). There was a moderate negative correlation between GLS and LVEF (r = −0.383, p  & lt;  0.001) and a weak positive correlation between TMAD and LVEF (r = 0.248, p  & lt;  0.001). There was strong negative correlation of TMAD with GLS (r = −0.614, p  & lt;  0.001). In a multivariable Cox regression analysis, TMAD was not associated with mortality (HR 1.04, 95 % CI 0.91–1.19), cardiac death (HR 1.03, 95 % CI 0.80–1.32) or cardiac events (HR 0.91, 95 % CI 0.80–1.02). TMAD is a quick and reproducible alternative to GLS which may be very use ful in cardiovascular risk assessment, but does not have the same prognostic value in HD patients as GLS. < /p >
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research