Pediatric Sudden Unexpected Death in Epilepsy: What Have we Learned from Animal and Human Studies, and Can we Prevent it?
Several factors, such as epilepsy syndrome, poor compliance, and increased seizure frequency increase the risks of sudden unexpected death in epilepsy (SUDEP). Animal models have revealed that the mechanisms of SUDEP involve initially a primary event, often a seizure of sufficient type and severity, that occurs in a brain, which is vulnerable to SUDEP due to either genetic or antecedent factors. This primary event initiates a cascade of secondary events starting, as some models indicate, with cortical spreading depolarization that propagates to the brainstem where it results in autonomic dysfunction.
In the face of COVID-19, neurologists working in stroke, epilepsy, dementia, and other subspecialties are tasked with a quick pivot from in-office patient visits to a new era of online consultations.Medscape Medical News
Publication date: May 2020Source: Epilepsy &Behavior, Volume 106Author(s): Kuo-Liang Chiang, Chin-Yin Huang, Liang-Po Hsieh, Kai-Ping Chang
In conclusion, microelectrode implantation surgeries modified some physiological and pathological behaviours; therefore, it is important to consider this fact when it is working with animal models. PMID: 32211080 [PubMed - in process]
Abstract Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to negative child health outcomes. Here, we review epidemiological and basic neuroscience work from the past several decades linking prenatal preeclampsia to altered neurodevelopment. This work demonstrates increased rates of neuropsychiatric disorders [e.g., increased autism spectrum disorder, attention deficit hyperactivity disorder (ADHD)] in children of preeclamptic pregnancies, as well as increased rates of cognitive impairments [e.g., decreased intelligence quotient (IQ), academic performance] and neurological disease (e...
ConclusionMost patients with temporal lobe epilepsy and CSF GAD65-Abs develop a chronic disease with progressive cognitive impairment and refractory epilepsy regardless of the presence of additional limbic symptoms at onset.
The review highlights contemporary views on the problem of suicide in patients with epilepsy. The most relevant theories are presented that describe the emergence of suicidal thoughts and the transition to suicidal attempts. Along with a description of ris...
AIM: To study a role of psychopathological and social factors in the development of suicidal behavior in patients with different forms of epilepsy. MATERIAL AND METHODS: One hundred and nineteen patients with epilepsy, 57 men and 62 women, mean age 40.7 ±0...
Publication date: Available online 25 March 2020Source: NeuroImage: ClinicalAuthor(s): Victoria L. Morgan, Catie Chang, Dario J. Englot, Baxter P. Rogers
Findings may have implications for understanding epilepsy, autism spectrum disorders.
Condition: Epilepsy Intractable Interventions: Procedure: Cathodal Transcranial Direct Current Stimulation; Procedure: Sham Transcranial direct current stimulation Sponsor: University of Campinas, Brazil Recruiting