The Combined Fixed-Dose Antituberculous Drugs Alter Some Reproductive Functions with oxidative stress involvement in Wistar Rats

Publication date: Available online 19 July 2016 Source:Toxicology Reports Author(s): O. Awodele, A.A. Momoh, N.A. awolola, O.E. kale The reproductive toxicity of combined fixed-dose first-line antituberculosis (CFDAT) regimen was assessed in rats. Thirty-two (32) Wistar rats weighing 168.1±8.0g were divided into four groups of eight rats per group. Two groups of male and female rats were administered oral distilled water (1.6ml) and CFDAT drugs containing rifampicin, isoniazid, pyrazinamide and ethambutol (RIPE, 92.5mg/m2 per body surface area) per male and female group respectively for forty-five days. Serum follicle stimulating hormone, luteinizing and testosterone were reduced significantly (p<0.05) in the treated male rats. Similarly, sperm count levels were decreased by 27.3% when compared with control. RIPE elevated serum oestrogen (p< 0.05), progesterone (p< 0.05) as well as prolactin (p> 0.05) levels in the treated females. In addition, RIPE reduced (p<0.05) total proteins levels and increased (p<0.05, 53%) catalase levels in male but not female animals. Superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, reduced glutathione levels as well as lipid peroxidation were unaltered in all rats respectively. Histopathological studies revealed congested peritesticular vessels and no changes in the ovary when compared with control. Overall, our results demonstrate reproductive toxicity potentials of RI...
Source: Toxicology Reports - Category: Toxicology Source Type: research