Penicisimpins A –C, three new dihydroisocoumarins from Penicillium simplicissimum MA-332, a marine fungus derived from the rhizosphere of the mangrove plant Bruguiera sexangula var. rhynchopetala

Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Rui Xu, Xiao-Ming Li, Bin-Gui Wang Three new dihydroisocoumarin derivatives, penicisimpins A–C (1–3), were isolated and identified from Penicillium simplicissimum MA-332, a fungus derived from the rhizosphere of the marine mangrove plant Bruguiera sexangula var. rhynchopetala. Their structures and absolute configurations were elucidated by extensive spectroscopic methods in combination with X-ray diffraction experiment. Compounds 1–3 exhibited brine shrimp (Artemia salina) lethality as well as broad-spectrum antimicrobial activities. Graphical abstract

Source: Phytochemistry Letters - July 23, 2016 Category: Chemistry Source Type: research