Penicillars A –E from the marine animal endogenic fungus Penicillium sp. SCS-KFD08

Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Fan Dong Kong, Li Man Zhou, Qing Yun Ma, Sheng Zhuo Huang, Pei Wang, Hao-Fu Dai, You-Xing Zhao Five new compounds named penicillars A–E were isolated from the fermentation broth of Penicillium sp. SCS-KFD08 associated with the marine animal Sipunculus nudus from the Haikou bay of China. Their planar structures and absolute configurations were unambiguously elucidated by spectroscopic data, Mo2(OAc)4 induced CD spectrum analysis along with quantum ECD calculation. Among them, compounds 2 and 3, at a concentration of 50μg/mL, showed weak inhibitory activity against AChE with inhibition rates of 19.5% and 21.3%, respectively. Graphical abstract

Source: Phytochemistry Letters - July 23, 2016 Category: Chemistry Source Type: research