New guaiane and acorane sesquiterpenes in high quality agarwood “Qi-Nan” from Aquilaria sinensis

Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Delan Yang, Jun Wang, Wei Li, Wenhua Dong, Wenli Mei, Haofu Dai Two new guaiane sesquiterpenes (1–2), one new acorane sesquiterpene (3), along with two known sesquiterpenes (4–5) were isolated from high quality agarwood ‘Qi-Nan’ originating from Aquilaria sinensis. Their structures were established based on spectroscopic methods including IR, HRESIMS, 1D, and 2D NMR. Compound 1 was a guaiane sesquiterpene lactone, and compound 2 was a guaiane sesquiterpene with a 5/6/7 ring carbon skeleton. Compounds 3 and 4 were acorane-type sesquiterpenes. The two acorane sesquiterpenes (3–4) possess lasting fragrant smell at room temperature. These isolated guaiane and acorane sesquiterpenes showed acetylcholinesterase inhibitory activities in different degrees ranged from 19% to 44% at the concentration of 50μg/mL. Graphical abstract

Source: Phytochemistry Letters - July 23, 2016 Category: Chemistry Source Type: research