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Weight loss may improve fertility in anovulatory obese women

HELSINKI – A 6-month lifestyle intervention was associated with an increased natural conception rate in infertile anovulatory obese women, compared with infertile ovulatory obese women, although the...
Source: Clinical Endocrinology News - Category: Endocrinology Source Type: news

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Publication date: Available online 17 April 2018 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Seema Patel Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, apart from a gamut of other metabolic co-morbidities such as insulin resistance, obesity, cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune disease, manifesting largely due to lifestyle errors. The advent of biochemical tests and ultrasound...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine pathology among women in reproductive age. Its main symptoms are oligo or amenorrhea, hyperandrogenism and the presence of ovarian cysts. It is also associated with infertility, obesity and insulin resistance. Mainly due to its heterogeneity, PCOS treatments are directed to manage its symptoms and to prevent associated diseases. The correct formation and regression of blood vessels during each ovarian cycle is indispensable for proper follicular development, ovulation and corpus luteum formation. The importance of these processes opened a new and promising fi...
Source: Reproduction - Category: Reproduction Medicine Authors: Tags: Reviews Source Type: research
Condition:   Endometrial Receptivity Intervention:   Sponsors:   Instituto Valenciano de Infertilidad, IVI VALENCIA;   IVI Bilbao;   IVI Barcelona;   Igenomix Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We examined relationships between maternal age (modeled flexibly to allow curvilinear shapes) and pregnancy outcomes using logistic regression. We plotted absolute predicted risks to display curves from age 20 to 50 estimated for two risk profiles: (1) population average values of all risk factors; (2) a low-risk profile without preexisting diabetes/hypertension, smoking, prior spontaneous/therapeutic abortion, diagnosed infertility, inadequate prenatal care, low income, rural residence, or obesity. Results: Risks of hypertensive disorders increased gradually until age 35, then accelerated. Risk of multiple gestations, ...
Source: Epidemiology - Category: Epidemiology Tags: Reproductive and Perinatal Source Type: research
Paternal obesity has been shown to have a negative impact on male fertility possibly due to increased aromatase activity from excess adipose tissue leading to decreased testosterone levels. Anastrozole, a non-steroidal aromatase enzyme competitive inhibitor, can increase endogenous testosterone production and has been associated with improved sperm counts. We sought to determine the outcomes of anastrozole therapy in the treatment of overweight or obese, sub-fertile males.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Infertility: Therapy II Source Type: research
Male infertility has multiple etiologies, many of which are treatable. Recent reports have demonstrated the deleterious impact of obesity on male fertility. Obese men often experience hypogonadism, typically secondary to hyperestrogenemia. This is presumably due to increased aromatase activity in body fat, resulting in impaired hormone and sperm production. The aim of this study is to investigate the effect of anastrazole on semen profiles in infertile men with hyperestrogenemia.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Infertility: Therapy II Source Type: research
(Natural News) According to the results of a study, women who take metformin, a common diabetes medication, could be putting their children at increased risk of being obese or overweight. More pregnant women with gestational diabetes or polycystic ovary syndrome (PCOS) are taking metformin to treat their conditions. PCOS usually causes infertility, and the condition can put...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Recent studies have suggested a role for abdominal obesity in male infertility. Previous studies have found that cell apoptosis exerts an important role in obesity-related male infertility. C1q/TNF-related protein 3 (CTRP3), a paralog of adiponectin, has been proposed to exert anti-apoptotic effects and to attenuate diabetes-related cardiac injuries. However, the role of CTRP3 in high-fat diet (HFD)-induced spermatogenic impairment remains unclear. In the present study, we fed male mice a HFD for 24 weeks to induce obesity. The expression of CTRP3 was decreased by HFD feeding. Supplementation with the recombinant human glo...
Source: Clinical Science - Category: Biomedical Science Authors: Tags: PublishAheadOfPrint Source Type: research
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