An enhanced version of Cochran-Armitage trend test for genome-wide association studies

Publication date: Available online 22 July 2016 Source:Meta Gene Author(s): Mansi Ghodsi, Saeid Amiri, Hossein Hassani, Zara Ghodsi Genome-wide association studies the evaluation of association between candidate gene and disease status is widely carried out using Cochran-Armitage trend test. However, only a small number of research papers have evaluated the distribution of p-values for the Cochran-Armitage trend test. In this paper, an enhanced version of Cochran-Armitage trend test based on bootstrap approach is introduced. The achieved results confirm that the distribution of p-values of the proposed approach fits better to the uniform distribution, and it is thus concluded that the proposed method, which needs less assumptions in comparison with the conventional method, can be successfully used to test the genetic association.

Source: Meta Gene - July 23, 2016 Category: Genetics & Stem Cells Source Type: research