Abstract < /h3 > < p class= " a-plus-plus " > In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, two polybrominated diphenyl ethers, 3,4,5-tribromo-2-(2 ′,4′-dibromophenoxy)-phenol ( < strong class= " a-plus-plus " > 1 < /strong > ) and 3,5-dibromo-2-(2 ′,4′-dibromophenoxy)-phenol ( < strong class= ..."> Abstract < /h3 > < p class= " a-plus-plus " > In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, two polybrominated diphenyl ethers, 3,4,5-tribromo-2-(2 ′,4′-dibromophenoxy)-phenol ( < strong class= " a-plus-plus " > 1 < /strong > ) and 3,5-dibromo-2-(2 ′,4′-dibromophenoxy)-phenol ( < strong class= ..." /> Abstract < /h3 > < p class= " a-plus-plus " > In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, two polybrominated diphenyl ethers, 3,4,5-tribromo-2-(2 ′,4′-dibromophenoxy)-phenol ( < strong class= " a-plus-plus " > 1 < /strong > ) and 3,5-dibromo-2-(2 ′,4′-dibromophenoxy)-phenol ( < strong class= ..." />

Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II

< h3 class= " a-plus-plus " > Abstract < /h3 > < p class= " a-plus-plus " > In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, two polybrominated diphenyl ethers, 3,4,5-tribromo-2-(2 ′,4′-dibromophenoxy)-phenol ( < strong class= " a-plus-plus " > 1 < /strong > ) and 3,5-dibromo-2-(2 ′,4′-dibromophenoxy)-phenol ( < strong class= " a-plus-plus " > 2 < /strong > ) were isolated from an Indonesian marine sponge of < em class= " a-plus-plus " > Dysidea < /em > sp. Compounds < strong class= " a-plus-plus " > 1 < /strong > and < strong class= " a-plus-plus " > 2 < /strong > showed the anti-proliferative activity against PANC-1 cells under glucose-starved conditions with IC < sub class= " a-plus-plus " > 50 < /sub > values of 2.1 and 3.8  µM, respectively, whereas no growth inhibition was observed up to 30 µM in the general culture conditions. The further mechanistic analysis indicated that compound < strong class= " a-plus-plus " > 1 < /strong > might act mainly by inhibiting complex II in the mitochondrial electron transport chain. < /p >
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research