Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release

Conclusion
Long-term effects of interval treadmill exercise training reduce ventricular tachycardia episodes in mice with a CPVT1-causative Ryr2 mutation through lower CaMKII-dependent phosphorylation of RyR2.

Source: Cardiovascular Research - July 21, 2016 Category: Cardiology Authors: Manotheepan, R., Danielsen, T. K., Sadredini, M., Anderson, M. E., Carlson, C. R., Lehnart, S. E., Sjaastad, I., Stokke, M. K. Tags: Ion Channels and Arrhythmias Source Type: research