Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform

Conclusions These findings establish that activation of the proteolytic processing of shCD146, in particular by sCD146, constitutes a promising pathway to improve endothelial progenitors' regenerative properties for the treatment of cardiovascular diseases.

http://cardiovascres.oxfordjournals.org/cgi/content/short/111/3/240?rss=1

Source: Cardiovascular Research - July 21, 2016 Category: Cardiology Authors: Stalin, J., Harhouri, K., Hubert, L., Garrigue, P., Nollet, M., Essaadi, A., Muller, A., Foucault-Bertaud, A., Bachelier, R., Sabatier, F., Pisano, P., Peiretti, F., Leroyer, A. S., Guillet, B., Bardin, N., Dignat-George, F., Blot-Chabaud, M. Tags: Vascular Biology Source Type: research