Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development

Conclusions
In contrast to in vitro studies, AKIP1 overexpression does not influence cardiac remodelling in response to chronic cardiac stress. AKIP1 does, however, reduce myocardial I/R injury through stabilization of the MPT pore. These findings suggest that AKIP1 deserves further investigation as a putative treatment target for cardioprotection from I/R injury during acute myocardial infarction.

Source: Cardiovascular Research - July 21, 2016 Category: Cardiology Authors: Booij, H. G., Yu, H., De Boer, R. A., van de Kolk, C. W. A., van de Sluis, B., Van Deursen, J. M., Van Gilst, W. H., Sillje, H. H. W., Westenbrink, B. D. Tags: Cardiac biology and remodelling Source Type: research