Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice

Conclusions Endothelial PTP1B deletion improves cardiac VEGF signalling and angiogenesis and protects against chronic afterload-induced heart failure. PTP1B may represent a useful target to preserve cardiac function during hypertrophy.

http://cardiovascres.oxfordjournals.org/cgi/content/short/111/3/204?rss=1

Source: Cardiovascular Research - July 21, 2016 Category: Cardiology Authors: Gogiraju, R., Schroeter, M. R., Bochenek, M. L., Hubert, A., Münzel, T., Hasenfuss, G., Schäfer, K. Tags: Cardiac biology and remodelling Source Type: research