An Integrated Experimental Design for the Assessment of Multiple Toxicological End Points in Rat Bioassays
Conclusion: This integrated study design is efficient in that the same generational cohort of rats used for evaluating long-term outcomes can be monitored in satellite parallel experiments to measure biomarkers and other parameters related to system-specific responses including metabolic alterations and endocrine disturbances.
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Citation: Manservisi F, Marquillas CB, Buscaroli A, Huff J, Lauriola M, Mandrioli D, Manservigi M, Panzacchi S, Silbergeld EK, Belpoggi F. An Integrated Experimental Design for the Assessment of Multiple Toxicological End Points in Rat Bioassays. Environ Health Perspect; http://dx.doi.org/10.1289/EHP419
Received: 12 October 2015
Revised: 27 April 2016
Accepted: 20 June 2016
Published: 22 July 2016
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Source: EHP Research - Category: Environmental Health Authors: Web Admin Tags: Commentary Source Type: research
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