An Integrated Experimental Design for the Assessment of Multiple Toxicological End Points in Rat Bioassays

Conclusion: This integrated study design is efficient in that the same generational cohort of rats used for evaluating long-term outcomes can be monitored in satellite parallel experiments to measure biomarkers and other parameters related to system-specific responses including metabolic alterations and endocrine disturbances. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Manservisi F, Marquillas CB, Buscaroli A, Huff J, Lauriola M, Mandrioli D, Manservigi M, Panzacchi S, Silbergeld EK, Belpoggi F. An Integrated Experimental Design for the Assessment of Multiple Toxicological End Points in Rat Bioassays. Environ Health Perspect; http://dx.doi.org/10.1289/EHP419 Received: 12 October 2015 Revised: 27 April 2016 Accepted: 20 June 2016 Published: 22 July 2016 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research