Supraventricular and Ventricular Arrhythmias are Related to the Type of Myotonic Dystrophy but not to Disease Duration or Neurological Status

BackgroundPatients with myotonic muscular dystrophy (dystrophia myotonica, DM) are at risk of sudden cardiac death due to diverse arrhythmias, especially progressive atrioventricular (AV) conduction abnormalities. However, there is limited data on supraventricular and potentially life‐threatening ventricular arrhythmias, especially according to type 1 and type 2 DM. MethodsA group of 94 unselected consecutive patients with genetically confirmed DM and 45 healthy controls underwent electrocardiography, echocardiography and 24‐h Holter monitoring. DM1 was diagnosed in 51, while DM2 in 43 patients (with mean age of 37.3±12.5 and 48.3±13.3 years, respectively). ResultsDM1 subjects presented more frequently intraventricular conduction defects (29.4 vs 6.6%, p = 0.0003) and 1st degree AV block (25.0 vs 4.6%, p = 0.008) than DM2 patients. Non‐sustained supraventricular tachycardia (37.2 vs 3.8%, p = 0.001) and non‐sustained ventricular tachycardia and/or R‐on‐T ventricular beats (23.2 vs 7.8%, p = 0.04) were more frequently observed in DM2 than in DM1. No relationship between disease duration and neurological status and occurrence of arrhythmias was observed. Multivariate analysis showed that independent predictor for bradyarrhythmias occurrence was DM1 only (OR 6.4, 95%CI 2.0‐20.8, p = 0.002), while for supraventricular or ventricular arrhythmias occurrence it was DM2 (OR 4.1, 95%CI 1.5‐11.4, p = 0.007) and increased age (OR 1.09, 95%CI 1.05‐1.15, p
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: ORIGINAL Source Type: research

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Muscular dystrophies are debilitating disorders that result in progressive weakness and degeneration of skeletal muscle. Although the genetic mutations and clinical abnormalities of a variety of neuromuscular diseases are well known, no curative therapies have been developed to date. The advent of genome editing technology provides new opportunities to correct the underlying mutations responsible for many monogenic neuromuscular diseases. For example, Duchenne muscular dystrophy, which is caused by mutations in the dystrophin gene, has been successfully corrected in mice, dogs, and human cells through CRISPR/Cas9 editing. ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Abstract Professor Andrew John Lees, from the National Hospital for Neurology and Neurosurgery, a neurological hospital in Queen Square, London, UK, has contributed in a stupendous way to the development of the field of movement disorders in Brazil, with a constant and intense participation in numerous congresses and scientific meetings of this specialty since 1983.Resumo O professor Andrew Lees, do National Hospital for Neurology and Neurosurgery, Queen Square, Londres, Reino Unido, tem contribu ído de maneira estupenda para o desenvolvimento da área dos distúrbios do movimento no Brasil, com uma part...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
CONCLUSION: We report the successful management of anesthesia without lethal arrhythmia in a patient with ARVC and an ICD. An adequate amount of analgesia should be administered during general anesthesia to maintain adequate anesthetic depth and to avoid stress and pain. PMID: 32473832 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
Conclusions Although ablation of CTI-dependent atrial flutter is a safe and effective procedure, 50% of the patients developed AF after the procedure. However, the role of combined ablation (CTI-dependent atrial flutter plus AF) aiming at preventing AF is still uncertain. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Conclusions Although ablation of CTI-dependent atrial flutter is a safe and effective procedure, 50% of the patients developed AF after the procedure. However, the role of combined ablation (CTI-dependent atrial flutter plus AF) aiming at preventing AF is still uncertain. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 1 June 2020Source: The Annals of Thoracic SurgeryAuthor(s): Giuseppe Nasso, Giuseppe Santarpino, Giuseppe Speziale
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
VERDICT: The hypothesis that the 4-aminoquinolines chloroquine and hydroxychloroquine may be beneficial in the treatment of COVID-19 is a weak one, based on poor mechanistic reasoning and inconsistent results of studies in vitro, in laboratory animals, and in humans. It is likely that even if chloroquine and hydroxychloroquine are effective in COVID-19, the beneficial effects will be small. The risks of adverse reactions to these drugs may be increased in patients who are acutely ill with severe COVID-19, in many of whom high doses are being used. Macrolide antibacterial drugs, such as azithromycin, clarithromycin, ery...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Condition:   Anorectal Disorder Intervention:   Other: Cough and Valsalva effort Sponsor:   Gérard Amarenco Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Epicardial fat from patients who develop POAF displays a specific pre-operative transcriptome signature c haracteristic of cellular immune response and cytotoxic lymphocyte enrichment.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Electrical stimulation (ES) by peripheral (transpalpebral/transorbital/transcorneal) approach seems to currently be one of the most promising rehabilitative techniques, which are aimed at the restoration of the visual function in low vision (LV) patients affected by degenerative diseases. The non-invasiveness of this methodology and its many positive effects on multiple retinal cell targets have led to the use of ES in patients with ischemic optic neuritis, traumatic optic nerve lesions, retinitis pigmentosa (RP), cone-rod dystrophy, Best disease, Stargardt disease, retinal vascular occlusions, glaucoma, and dry and wet ag...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
More News: Arrhythmia | Atrial Fibrillation | Cardiology | Electrocardiogram | Genetics | Muscular Dystrophy | Neurology | Reflex Sympathetic Dystrophy | Ventricular Tachycardia