Research in Maori Community Yields Hope for Huntington ’ s

I have just returned from a couple weeks in New Zealand, where I am collaborating with Dr. Melanie Cheung and others on a pretty incredible Huntington’s disease project. I am so inspired by what we’re doing there that I wanted to share a bit about it. More than 7,000 of the 4.5 million citizens of […]The post Research in Maori Community Yields Hope for Huntington’s appeared first on "On the Brain" with Dr. Michael Merzenich.
Source: On the Brain by Dr. Michael Merzenich, Ph.D. - Category: Neuroscience Authors: Tags: Brain Plasticity Brain Science Cognitive impairments Neuroscience Posit Science HD huntington's maori melanie cheung new zealand Source Type: blogs

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AbstractHuntington ’s disease (HD) is a rare neurodegenerative disorder of the central nervous system characterized by involuntary choreatic movements, cognitive, behavioral, and psychiatric disturbances. Most HD suffer from dysphagia and aspiration pneumonia is the leading cause of death. However, little is known a bout dysphagia management in HD. A revision of the literature was conducted to depict the state of the art on the assessment and treatment of dysphagia in HD. Literature search of the last 10 years was performed using PubMed and EMBASE. Twenty-four studies were included: 16 cross-sectional studies, 2...
Source: Neurological Sciences - Category: Neurology Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Treatment-refractory psychosis (TRP) is a controversial term in the setting of the current societal stigma and medical understanding or misunderstanding of mental illness. However, there is recognition that patients with either advanced mental illness (i.e. schizophrenia) in the setting of terminal diseases such as cancer or certain neurologic diseases (i.e. Huntington's disease and Lewy body dementia) can result in psychotic states not amendable to conventional pharmacologic and non-pharmacologic treatments.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
Allogeneic haematopoietic stem cell transplantation (alloSCT) cures cancer, but is associated with significant side effects such as graft versus host disease (GVHD) and infection. In order to improve patient outcomes, we need to reduce pre-transplant conditioning, promote donor cell engraftment and limit GVHD. Natural killer (NK) cells are important for controlling donor cell engraftment, and are reliant on BCL2 and JAK1/2 pathways for survival. We investigated if NK cells could be depleted from the immune system prior to alloSCT, using the clinically approved BCL2 inhibitor Venetoclax, and the JAK1/2 inhibitor Ruxolitinib.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 248 Source Type: research
Mitochondria are the power plants of the cell. A herd of these bacteria-like organelles in every cell manufacture the chemical energy store molecules that are used to power cellular processes. Mitochondrial function declines with age throughout the body. Evidence suggests that this is due to changes in mitochondrial dynamics that inhibit the quality control mechanisms of mitophagy that are responsible for recycling worn and damaged mitochondria. This loss of miochondrial function is well known to contribute to the progression of neurodegenerative conditions, as the brain is an energy-hungry organ, making this an important ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Molecules, Vol. 25, Pages 482: Huntington’s Disease: A Review of the Known PET Imaging Biomarkers and Targeting Radiotracers Molecules doi: 10.3390/molecules25030482 Authors: Klaudia Cybulska Lars Perk Jan Booij Peter Laverman Mark Rijpkema Huntington’s disease (HD) is a fatal neurodegenerative disease caused by a CAG expansion mutation in the huntingtin gene. As a result, intranuclear inclusions of mutant huntingtin protein are formed, which damage striatal medium spiny neurons (MSNs). A review of Positron Emission Tomography (PET) studies relating to HD was performed, including clinical an...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
(Duke University) A Duke University research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative disorder known as Huntington's Disease. Using genetic mouse models, they have discovered that neurons in the striatum, a brain area involved in controlling movement, require the huntingtin gene for regulating the body's movements, maintaining cell health during aging, and developing functioning connections between cells.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Myelin is the sheathing of nerves, essential to their function. Excessive loss produces disabling and ultimately fatal conditions such as multiple sclerosis, but we all lose myelin integrity to some degree as a consequence of the damage and dysfunction of degenerative aging. This most likely contributes to cognitive decline and other age-related issues. A number of different approaches have been identified to boost the operation of the normal maintainance processes that remyelinate nerves, such as FGF21 upregulation, or increasing the size of remyelinating cell populations. Here, researchers discover another possible trigg...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ino A Abstract Neurodegenerative diseases affect millions of people around the world. Several studies point out caspase-3 as a key player in the development and progression of neurological disorders including amyotrophic lateral sclerosis, Alzheimer's, Parkinson's and Huntington's diseases. Furthermore, oxidative stress and mitochondrial dysfunction plays an important role in neurodegenerative pathologies leading to neuronal damage and cell death. Pharmacological properties of nitrones such as free radical trapping and neuroprotection has been previously described. In the present work, we have assessed ten non-cyt...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
Huntington's disease-like 2 (HDL-2) is an autosomal dominant neurodegenerative disorder caused by a CTG/CAG trinucleotide repeat expansion ( ≥40 repeats) in the junctophilin-3 gene on chromosome 16q24.3 [1]. The affected protein product, junctophilin-3, plays a role in anchoring the endoplasmic reticulum to the plasma membrane. The disorder generally manifests in mid-life as a Huntington's disease (HD) phenocopy syndrome comprising cog nitive decline, neuropsychiatric manifestations and movement disorders (generally chorea) [2,3].
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research
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