Liver X Receptor- α polymorphisms (rs11039155 and rs2279238) are associated with susceptibility to vitiligo

In this study, for the first time, we have investigated the association of LXR-α gene polymorphisms and risk of vitiligo. Sixty six vitiligo patients and 75 matched healthy control subjects who did not have any history of vitiligo or any other autoimmune disorder were recruited. The DNA isolated from patients and healthy controls was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for both rs11039155 (−6 G>A) and rs2279238 (+1257 C>T) variants. Our data suggest significant association between the LXR-α gene polymorphisms and vitiligo susceptibility (rs11039155: odds ratio (OR)=1.99, 95% CI=1.07–3.71, p=0.03; rs2279238: OR=1.70, 95% CI=1.06–2.73, p=0.027). Our results provide an evidence that the LXR-α −6A and +1257T alleles contribute to risk of vitiligo in North Indian population and highlight the importance of this gene in the vitiligo pathogenesis.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research