Effect of Selective Prostaglandin E2 EP2 Receptor Agonist CP ‐533,536 on Voiding Efficiency in Rats with Midodrine‐Induced Functional Urethral Obstruction

ConclusionsThese results suggest that a selective EP2 receptor agonist could ameliorate the elevation of RV and improve the reduction of VE in rats with functional urethral obstruction caused by stimulation of α1‐adrenoceptors. The mechanism of action might be not potentiation of bladder contraction but rather preferential relief of urethral constriction.
Source: LUTS: Lower Urinary Tract Symptoms - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research