A surfactant ‐based wound dressing can reduce bacterial biofilms in a porcine skin explant model

Abstract Bacterial biofilms have been found in many, if not all, chronic wounds. Their excessive extracellular matrix secretion and the metabolic changes that they undergo render them highly tolerant of many antibiotic and antimicrobial treatments. Physical removal and/or disruption are a common approach to treating wounds suspected of having bacterial biofilms. While many of these techniques use mechanical energy as the primary means of removal, we have begun to investigate if surfactants could facilitate the removal of bacterial biofilms, or if they might sensitise the biofilms to antimicrobial interventions. We tested a new surfactant‐based wound gel on an ex vivo porcine skin explant model infected with a functionally tolerant 3‐day biofilm. The wounds were dressed with a surfactant‐based gel directly on the wound or with moistened gauze. The wounds were then wiped daily with moistened gauze, and the gel or gauze was re‐applied. Each day, an explant from each group was harvested and tested for total viable bacteria counts and viable biofilm‐protected bacteria counts. The results show that daily wiping with moistened gauze led to an initial decrease of bacteria, but by day 3, the biofilm had been fully re‐established to the same level prior to the beginning of treatment. For the surfactant‐based treatment, there was no detectable functional biofilm after the first treatment. The gauze control, which was also subjected to daily wiping, still contained function...
Source: International Wound Journal - Category: Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Abstract OBJECTIVE: Using a feasibility analysis and matched subgroup analysis, this study investigated the implementation/safety/outcomes of a stroke recovery program (SRP) integrating modified cardiac rehabilitation for stroke survivors. DESIGN: This prospective cohort study of 783 stroke survivors were discharged from an inpatient rehabilitation facility to an outpatient setting; 136 SRP-participants completed a feasibility study and received the SRP including modified cardiac rehabilitation, 473 chose standard of care rehabilitation (nonparticipants), and a group (n = 174) were excluded. The feasibility s...
Source: Health Physics - Category: Physics Authors: Tags: Am J Phys Med Rehabil Source Type: research
Publication date: Available online 21 October 2019Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Girish P. Joshi, Francis Bonnet
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
ConclusionsThis case series demonstrates that the use of a high frequency jet ventilator for cardiac MRI was feasible, safe, providing good quality cardiac imaging and avoiding anesthesia personnel to be inside the hazardous environment of MRI room. Future studies are needed to confirm its safety and efficiency in pediatric patients.ResumoJustificativa e objetivosA ressonância magnética (RM) cardíaca é uma técnica utilizada na avaliação de crianças com cardiopatias congênitas. A anestesia geral garante imobilidade, especialmente em pacientes não cooperador...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
This article focuses on the functional features of positive-pressure ventilators, the modes of invasive and non-invasive mechanical ventilation, and the main ventilator settings. It also highlights the potential complications of mechanical ventilation, the basic principles of weaning, and the pathophysiological basis of patient-ventilator dyssynchrony.
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
In conclusion, this review reported that IL-37 has a crucial role in reducing infection-associated inflammation and has a good impact on inflammation-induced pathology. However, tight regulation that achieved balance between effector immune responses that required for pathogen elimination and limited tissue damage that resulted from excessive inflammation should be existed in the potential IL-37 therapy to prevent clinical complications of a disease. PMID: 31633447 [PubMed - as supplied by publisher]
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
Date: Monday, 10 21, 2019; Speaker: See attached agenda; Building 10; Masur (10/21/19) and Lipsett (10/22/19)
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Wednesday, 10 23, 2019; Speaker: Joseph Zaia, Ph. D., Boston University; Building 50; 1227/1233; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Thursday, 10 24, 2019; Speaker: Bruce Tromberg, NIBIB Director, NIBIB/ NIH; Dr. Susan Gregurick, Associate Director for Data Science, NIH; Building: Building 45 (Natcher Building); Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Thursday, 10 24, 2019; Speaker: Joachim Lingner, Ph.D., Full Professor for Life Sciences, EPF Lausanne (Swiss Federal Institute of Technology); Building: Building 37; Conference Room 6041/6107
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Monday, 10 28, 2019; Speaker: Xiangbo Ruan, Regulation of systemic lipid metabolism by human lncRNAs, The Cao group, CB, NHLBI; Ranganath Muniyappa, Hyperuricemia in insulin resistance, DEOB, NIDDK; Building: Building 10 (Clinical Center); Solarium Conference Room 9S233 (old Bunim Room)
Source: NIH Calendar of Events - Category: American Health Source Type: events
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