Brigham and Women ’s Researchers Present Findings at the 10th Annual AACR International Conference on Frontiers in Cancer Prevention Research

Researchers find links between coffee consumption and skin cancer risk, tanning bed use and skin cancer risk, and analgesic use and renal cell carcinoma.
Source: BWH for Journalists - Category: Research Source Type: news

Related Links:

This review focuses on what is the biological basis of esophageal cancer for immunotherapy, how to screen out the patients who can benefit from immunotherapy, and whether the toxic side effects of immunotherapy are manageable. AbstractConsidering the benefits of immunotherapy in advanced melanoma, non –small cell lung cancer, renal cell carcinoma, bladder cancers, and refractory Hodgkin lymphoma, we begin to consider whether immunotherapy is effective for esophageal cancer, which is extremely malignant and has a poor prognosis. There are a large number of clinical trials to study the applicatio n of immunotherapy suc...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: REVIEW Source Type: research
Surveillance imaging in patients with a history of solid organ malignancies has led to increased identification of asymptomatic adrenal masses, which raises clinical ambiguity in patients with known prior or concurrent malignancies. Single adrenal masses (incidentalomas) are found incidentally in 2%-9% of all abdominal CT scans. Adrenal metastases are most commonly seen in renal cell carcinoma, melanoma, lung cancer, colon cancer and lymphoma. The involvement of adrenal gland upstages the disease.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Tuesday abstract Source Type: research
Lung cancer remains the leading cause of cancer deaths worldwide[1]. Non-small cell lung cancer (NSCLC) represents 80-90% of lung primary malignancies. NSCLC is most often diagnosed at a metastatic stage, where 5-year survival rate ranges between 0 and 5% using traditional chemotherapy-based strategies[2]. The recent introduction of immune checkpoint inhibitors (ICI), has resulted in an increase in overall survival (OS) rates of patients with advanced NSCLC, as well as melanoma, urothelial carcinoma, renal cell carcinoma and head and neck carcinoma.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Conclusions: To develop small molecule-based PD-L1 PET imaging probes, we designed and synthesized a library of fluorinated PD-L1 ligands based on the biphenyl pharmacophore. In vitro binding assay showed that several of the compounds possess nano-molar affinities to human PD-L1, and are potential PD-L1 PET imaging probe candidates. The radiolabeling and in vitro and in vivo pharmacology and pharmacokinetics studies of these PET tracers are under the way. Figure 1. The structure of the lead compound and the regions for SAR
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Novel Radiochemistry for Cancer Applications Source Type: research
AbstractCancer cells can escape the immune system by different mechanisms. The evasion of cancer cells from immune surveillance is prevented by immune checkpoint inhibitors, allowing the patient ’s own immune system to attack their cancer. Immune checkpoint inhibitors have shown improvement in overall survival for melanoma, lung cancer and renal cell carcinoma in clinical trials. Unfortunately, not all patients respond to this therapy.In cancer management, percutaneous ablation techniques are well established for both cure and local control of many tumour types. Cryoablation of the tumour tissue results in cell destr...
Source: Insights into Imaging - Category: Radiology Source Type: research
This report is about a patient with metastastic squamous cell cancer of the head and neck refractory to nivolumab monotherapy, who showed a remarkable response to combination therapy with nivolumab and ipilimumab over a period of 2 years, but developed serious renal failure and a Takotsubo cardiomyopathy.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Immune checkpoint inhibition (ICI) targeting the programmed death receptor 1 (PD-1) has shown promising results in the fight against cancer. Systemic anti-tumor reactions due to radiation therapy (RT) can lead to regression of non-irradiated lesions (NiLs), termed "abscopal effect" (AbE). Combination of both treatments can enhance this effect. The aim of this study was to evaluate AbEs during anti-PD-1 therapy and irradiation. We screened 168 patients receiving pembrolizumab or nivolumab at our center. Inclusion criteria were start of RT within 1 month after the first or last application of pembrolizumab (2mg/kg...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: We propose that PD-L2 as well as PD-L1 play important roles in evading antitumor immunity, suggesting that PD-1/PD-L2 blockade must be considered for optimal immunotherapy in PD-L2-expressing cancers, such as RCC and LUSC. PMID: 31076547 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
ConclusionsThese two cases suggest that indels might be a new predictor of PD-1 blockade response for ICC patients beside PD-L1 expression, TMB, MSI, and dMMR, warranting further clinical investigation.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
hiodoni The so-called immune checkpoints are pathways that regulate the timing and intensity of the immune response to avoid an excessive reaction and to protect the host from autoimmunity. Immune checkpoint inhibitors (ICIs) are designed to target the negative regulatory pathways of T cells, and they have been shown to restore anti-tumor immune functions and achieve considerable clinical results. Indeed, several clinical trials have reported durable clinical response in different tumor types, such as melanoma, renal cell carcinoma (RCC) and non-small cell lung cancer (NSCLC). Nonetheless, after the initial enthusiasm,...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Conferences | Kidney Cancer | Renal Cell Carcinoma | Research | Skin | Skin Cancer | Women