Can Your Antacid Cause Alzheimer ’s Disease?
Can your antacid really cause Alzheimer’s Disease? Recent research suggests that, indeed, proton pump inhibitors, some of the most common drugs for reducing feelings of heartburn, can cause an increase in the ‘beta amyloid’ deposits in the brain that are indicative of Alzheimer’s Disease. This is in addition to some of the other serious Proton Pump Inhibitor Side Effects, like osteoporosis, magnesium deficiency and heart rhythm problems; Antacid Medications can Even Ruin Your Gut. These problems can occur even when these heartburn relieving drugs are taken for short amounts of time. All too often, though, these drugs, with names like: Omeprazole Lansoprazole Pantoprazole Esomeprazole Rabeprazole and other drugs in the same class are taken for many years, which can cause Alzheimer’s at a much higher rate than those who do not take them. Is the risk of permanent loss of memory worth it for temporary heartburn relief that can be accomplished using other means that don’t cause Alzheimer’s? Solving the underlying problem can even DECREASE the risk of dementia and Alzheimer’s, rather than increasing the risk with dangerous drugs. “Studies have shown that proton pump inhibitors (PPIs) increase the brain burden of amyloid-beta (Aβ) and also create vitamin B12 deficiency. However, these two phenomena have deleterious effect on cognition and Alzheimer’s disease (AD).” Cognitive impact after short-term expos...
Abstract The vitamin D pathway is related to the mass and function of skeletal muscles. Several studies have demonstrated the role of vitamin D receptor (VDR) and CYP27B1 in skeletal muscles, suggesting that these proteins may regulate skeletal muscles and their function. However, it remains unclear whether the expression of VDR and CYP27B1 is modified in skeletal muscle atrophy. We investigated whether denervation-induced muscle atrophy is associated with altered expression of VDR and CYP27B1 in murine skeletal muscles. Skeletal muscles were excised from C57BL/6J mice, 3 and 7 days after the mice underwent denerv...
In conclusion, there is a relationship between DNA methylation and PIO. AzadC has a certain inhibitory effect on osteolysis induced by titanium particles. Regulating DNA methylation may be a new way to treat PIO. Our findings lay a foundation for epigenetic understanding and intervention of osteolysis. PMID: 32736684 [PubMed - as supplied by publisher]
Publication date: Available online 1 August 2020Source: Journal of Alloys and CompoundsAuthor(s): Mingyang Ma, Durga Bhakta Pokharel, Junhua Dong, Liping Wu, Runying Zhao, Yue Zhu, Jiaru Hou, Jieya Xie, Shuanghui Sui, Changgang Wang, Wei Ke
Publication date: Available online 30 July 2020Source: Journal of Hazardous MaterialsAuthor(s): Yu-Chi Chang, Jun-Yen Uan
A VITAMIN B12 DEFICIENCY can occur over time, as the body struggles to absorb the nutrient from the foods you eat. Eventually, you may start to notice problems with your nervous system - are you experiencing a 'strange' sensation?
Publication date: Available online 1 August 2020Source: Journal of Materials Processing TechnologyAuthor(s): Wenbo Yu, Chaosheng Ma, Yihu Ma, Shoumei Xiong
Around half the world’s population is deficient in vitamin D. → Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice. To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the tr...
In conclusion, while our results certainly support and confirm the efficacy of Denosumab in Osteoporosis, we discourage the use of Denosumab in addition to conventional chemotherapy in Osteosarcoma, even though, certainly further investigations are necessary to better clarify the clinical role of this monoclonal antibody in cancer. PMID: 32733647 [PubMed]
Can your antacid really cause Alzheimer’s Disease? Recent research suggests that, indeed, proton pump inhibitors, some of the most common drugs for reducing feelings of heartburn, can cause an increase in the ‘beta amyloid’ deposits in the brain that are indicative of Alzheimer’s Disease. This is in addition to some of the other serious Proton Pump Inhibitor Side Effects, like osteoporosis, magnesium deficiency and heart rhythm problems; Antacid Medications can Even Ruin Your Gut. These problems can occur even when these heartburn relieving drugs are taken for short amounts of time. All too of...
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