Abstract < /h3 > < p class= " a-plus-plus " > As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mTOR) emerges as a novel therapeutic target for Parkinson ’s disease (PD). A growing body of research indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal cell death. Nevertheless, molecular mechanisms unde..."> Abstract < /h3 > < p class= " a-plus-plus " > As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mTOR) emerges as a novel therapeutic target for Parkinson ’s disease (PD). A growing body of research indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal cell death. Nevertheless, molecular mechanisms unde..." /> Abstract < /h3 > < p class= " a-plus-plus " > As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mTOR) emerges as a novel therapeutic target for Parkinson ’s disease (PD). A growing body of research indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal cell death. Nevertheless, molecular mechanisms unde..." />

mTOR Signaling in Parkinson ’s Disease

< h3 class= " a-plus-plus " > Abstract < /h3 > < p class= " a-plus-plus " > As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mTOR) emerges as a novel therapeutic target for Parkinson ’s disease (PD). A growing body of research indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal cell death. Nevertheless, molecular mechanisms underlying mTOR-mediated effects in PD have not been fully understood yet. Here, we review recent progress in characterizin g the association of mTOR signaling with PD risk factors and further discuss the potential roles of mTOR in PD. < /p >
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research