Mouse Study Offers Hope for Vaccine Against Chlamydia

THURSDAY, July 21, 2016 -- A new Canadian study with mice suggests there is hope for a vaccine to protect against chlamydia, a common, sexually transmitted infection that can render young women infertile if left untreated. The vaccine works by...
Source: Drugs.com - Daily MedNews - Category: Journals (General) Source Type: news

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Sexually transmitted disease (STD) rates in the U.S. are at a record high for the fourth year in a row, according to new data from the Centers for Disease Control and Prevention (CDC). All told, nearly 2.3 million cases of chlamydia, gonorrhea and syphilis were diagnosed in the U.S. in 2017. That’s 200,000 more cases than were diagnosed in 2016, a year that also had a record-high number of cases, according to the CDC. “We are now very concerned about this steep and sustained increase that we’re seeing,” says Dr. Gail Bolan, the director of the CDC’s Division of STD Prevention. “We’...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime Sex/Relationships Source Type: news
The National Institute of Allergy and Infectious Diseases has invented three chlamydial vaccine technologies, which have shown promising preclinical efficacy. Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection. If left untreated, chlamydia infection can lead to pelvic inflammatory disease and infertility. Chlamydia is also the leading cause of preventable blindness in the world. Despite increased surveillance, prevalence continues to increase, and the need to develop an effective chlamydial vaccine remains.Technologies: 1. A plasmid-deficient Chlamydia trachomatis strain which was s...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
National institute of allergy and infectious diseases workshop report: "Chlamydia vaccines: the way forward". Vaccine. 2017 Oct 30;: Authors: Zhong G, Brunham RC, de la Maza LM, Darville T, Deal C Abstract Chlamydia trachomatis (Ct), an intracellular pathogen, is the most common bacterial sexually transmitted infection. In addition to acute cervicitis and urethritis, Ct can lead to serious sequelae of significant public health burden including pelvic inflammatory disease (PID) and infertility. Ct control efforts have not resulted in desired outcomes such as reduced incidence and reinfection,...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
This report presents baseline estimates of the use of these preventive services before the publication of QFP that can be used to monitor progress toward improving the quality of preventive care received by women and men of reproductive age. PERIOD COVERED: 2011-2013. DESCRIPTION OF THE SYSTEM: Three surveillance systems were used to document receipt of preventive health services among women and men of reproductive age as recommended in QFP. The National Survey of Family Growth (NSFG) collects data on factors that influence reproductive health in the United States since 1973, with a focus on fertility, sexual act...
Source: MMWR Surveill Summ - Category: Epidemiology Authors: Tags: MMWR Surveill Summ Source Type: research
Chlamydia is a prevalent sexually transmitted disease that infects more than 100 million people worldwide. Although most individuals infected with Chlamydia trachomatis are initially asymptomatic, symptoms can arise if left undiagnosed. Long-term infection can result in debilitating conditions such as pelvic inflammatory disease, infertility, and blindness. Chlamydia infection, therefore, constitutes a significant public health threat, underscoring the need for a Chlamydia-specific vaccine. Chlamydia strains express a major outer-membrane protein (MOMP) that has been shown to be an effective vaccine antigen. However, appro...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Membrane Biology Source Type: research
Discussion Of the 30 different microbes which can be transmitted by sexual contact, 8 have the greatest incidence of transmitting disease. Four are curable (Chlamydia, Gonorrhea, Syphilis and Trichomoniasis) and 4 are incurable at present (Hepatitis B, Herpes simplex virus (HSV), Human immunodeficiency virus (HIV) and Human papillomavirus (HPV)). Sexually transmitted infections (STIs) are important as they can cause: Increased rates of acquisition of other STIs (ie HSV and syphilis increase the rate of HIV infection acquisition) Pelvic inflammatory disease and infertility Stillbirth and neonatal death Neonatal morbidity i...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Conclusion This large study found an association between having the MeNZB vaccine and a reduced likelihood of being diagnosed with gonorrhoea. But it's difficult to form any firm conclusions because of the nature of the case and control groups. For example, given that both groups were sexually active, we don't know why the majority of people with gonorrhoea didn't also have a chlamydia infection, and how this may have affected the results. It could just be down to pure chance and have nothing to do with the vaccine. So before we celebrate the alleged "cure of gonorrhoea", there are many things to consider: T...
Source: NHS News Feed - Category: Consumer Health News Tags: Medication Source Type: news
We describe the clinical and public health need for a C. trachomatis vaccine, provide an overview of Chlamydia vaccine development efforts, and summarize current vaccine candidates in the development pipeline. PMID: 28111145 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Conclusion It's easy to get carried away by headlines about vaccines for common and damaging diseases, but early-stage studies in mice don't always translate into usable vaccines for humans. People have been trying to find an effective vaccine against chlamydia since the bacteria was discovered in 1957, and research is still being carried out into several different vaccine candidates. This vaccine may turn out to be effective, but it could become one of the many failed vaccine candidates seen over the years. This is a small study in just 20 specially bred laboratory mice, and involved a type of chlamydia (Chlamydia muri...
Source: NHS News Feed - Category: Consumer Health News Tags: Lifestyle/exercise Medication Medical practice Source Type: news
Authors: Poston TB, Darville T Abstract Chlamydia trachomatis is the most common cause of sexually transmitted bacterial infection globally. These infections translate to a significant public health burden, particularly women's healthcare costs due to serious disease sequelae such as pelvic inflammatory disease (PID), tubal factor infertility, chronic pelvic pain, and ectopic pregnancy. There is no evidence that natural immunity can provide complete, long-term protection necessary to prevent chronic pathology, making human vaccine development critical. Vaccine design will require careful consideration of protective...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
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