Benefit & ndash;risk assessment of golimumab in the treatment of refractory ulcerative colitis

Source: Drug, Healthcare and Patient Safety - Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

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Publication date: Available online 16 October 2019Source: International Journal of PharmaceuticsAuthor(s): Anastasia Foppoli, Alessandra Maroni, Saliha Moutaharrik, Alice Melocchi, Lucia Zema, Luca Palugan, Matteo Cerea, Andrea GazzanigaAbstract5-aminosalicylic acid (5-ASA) is the most widely used drug for the treatment of ulcerative colitis. The benefits of targeted delivery of 5-ASA to the large intestine are well known, resulting in reduced systemic absorption and increased local concentrations at the disease site. In the present study, a 5-ASA colon delivery system based on the time-dependent strategy, exploiting the r...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Condition:   Ulcerative Colitis Interventions:   Drug: GS-4875;   Drug: Placebo Sponsor:   Gilead Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Ulcerative Colitis;   Artificial Intelligence;   Confocal Laser Endomicroscopy Intervention:   Diagnostic Test: The diagnosis of Artificial Intelligence and endoscopist Sponsor:   Shandong University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Clinical / Medical
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
Tim G.J. de Meij Endoscopic evaluation is mandatory in establishing the diagnosis of pediatric inflammatory bowel disease (IBD), but unfortunately carries a high burden on patients. Volatile organic compounds (VOC) have been proposed as alternative, noninvasive diagnostic biomarkers for IBD. The current study aimed to assess and compare the potential of fecal and urinary VOC as diagnostic biomarkers for pediatric IBD in an intention-to-diagnose cohort. In this cohort study, patients aged 4–17 years, referred to the outpatient clinic of a tertiary referral center under suspicion of IBD, were eligible to par...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
ConclusionThese observations provide compelling evidence that BLFE could be considered as a viable natural strategy in the prevention and management of ulcerative colitis.Graphic abstract
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
Kamila Migacz-Gruszka, Wojciech Branicki, Aleksander Obtulowicz, Magdalena Pirowska, Krystian Gruszka, Anna Wojas-PelcInternational Journal of Trichology 2019 11(5):185-188 The term “microbiome” defines the collective genome of all commensal, symbiotic, and pathogenic microbes living in the human body. The composition of microbiota in the gut and skin is influenced by many factors such as the stage of life, nutrition, lifestyle, and gender. In the past few years, several scientific papers have demonstrated an implication of microbiota in many immune-mediated diseases, for example, diabetes, ulcerative colitis,...
Source: International Journal of Trichology - Category: Dermatology Authors: Source Type: research
Authors: Su H, Kang Q, Wang H, Yin H, Duan L, Liu Y, Fan R Abstract [This corrects the article DOI: 10.3892/etm.2019.7253.]. PMID: 31608129 [PubMed - in process]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
A nested qualitative interview study within the CONSTRUCT trial was conducted to explore experiences and perceptions of patients with acute severe ulcerative colitis following treatment with infliximab or cicl...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Research article Source Type: research
Nature Reviews Gastroenterology &Hepatology, Published online: 15 October 2019; doi:10.1038/s41575-019-0225-8New trials in ulcerative colitis therapies
Source: Nature Reviews Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
More News: Drugs & Pharmacology | Inflammatory Bowel Disease | Ulcerative Colitis